Increased incidence of stent thrombosis in patients with cocaine use

Gudjon Karlsson, Jalees Rehman, Vijay Kalaria, Jeffrey A. Breall

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Introduction: Coronary stent thrombosis is a rare occurrence in the era of dual-anti-platelet therapy. It is not known whether patients who use cocaine have a higher risk of thrombosis following coronary stent placement. Methods: We studied 247 consecutive patients who underwent coronary stent placement at an inner-city hospital. Results: Twelve patients (4.9%) were actively using cocaine at the time of PCI. Of these twelve patients, four patients presented with stent thrombosis (33%) at a mean of 51 ± 40 days (median 45 days), after the index revascularization procedure. Only 2 of the 235 patients without documented cocaine use (0.85%) had stent thrombosis during the same period (P < 0.0001). Conclusion: The patients who actively use cocaine have a markedly higher risk of stent thrombosis when compared with patients without a documented history of cocaine use. We discuss various factors that potentially predispose cocaine users to stent thrombosis.

Original languageEnglish (US)
Pages (from-to)955-958
Number of pages4
JournalCatheterization and Cardiovascular Interventions
Volume69
Issue number7
DOIs
StatePublished - Jun 1 2007

Keywords

  • Cocaine use
  • Percutaneous coronary intervention
  • Stent
  • Stent thrombosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

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