Increased levels of CSF phosphorylated tau in apolipoprotein E ε4 carriers with mild cognitive impairment

Katharina Buerger, Stefan J. Teipel, Raymond Zinkowski, Trey Sunderland, Niels Andreasen, Kaj Blennow, Michael Ewers, John DeBernardis, Yong Shen, Daniel Kerkman, Yansheng Du, Harald Hampel

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

We investigated the correlation between the apolipoprotein E ε4 allele (apoE ε4) carrier status, a major risk factor of Alzheimer's disease (AD), and levels of tau protein phosphorylated at threonine 231 (P-tau 231P) in cerebrospinal fluid (CSF) in predementia and clinical stages of AD and healthy controls (HC). Thirty-one subjects with mild cognitive impairment (MCI) who had converted to AD during follow-up were included, as well as 71 AD patients, and 29 HC subjects. In MCI, but not in AD and HC, CSF P-tau231P levels were significantly higher in apoE ε4 carriers compared to non-carriers (p < 0.001). Controlling for disease duration, the apoE ε4 effect on P-tau231P remained significant. Our study indicates that the apoE ε4 carrier status should be considered when CSF P-tau231P is evaluated as biomarker candidate of AD in MCI subjects.

Original languageEnglish (US)
Pages (from-to)48-50
Number of pages3
JournalNeuroscience Letters
Volume391
Issue number1-2
DOIs
StatePublished - Dec 31 2005

Keywords

  • Alzheimer's disease
  • Apolipoprotein E
  • Cerebrospinal fluid
  • Mild cognitive impairment
  • Phosphorylated tau protein
  • Risk factor

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Increased levels of CSF phosphorylated tau in apolipoprotein E ε4 carriers with mild cognitive impairment'. Together they form a unique fingerprint.

  • Cite this

    Buerger, K., Teipel, S. J., Zinkowski, R., Sunderland, T., Andreasen, N., Blennow, K., Ewers, M., DeBernardis, J., Shen, Y., Kerkman, D., Du, Y., & Hampel, H. (2005). Increased levels of CSF phosphorylated tau in apolipoprotein E ε4 carriers with mild cognitive impairment. Neuroscience Letters, 391(1-2), 48-50. https://doi.org/10.1016/j.neulet.2005.08.030