Increased Likelihood of Glaucoma at the Same Screening Intraocular Pressure in Subjects With Pseudoexfoliation

The Thessaloniki Eye Study

Fotis Topouzis, Alon Harris, M. Roy Wilson, Archimidis Koskosas, Panayiota Founti, Fei Yu, Eleftherios Anastasopoulos, Theofanis Pappas, Anne L. Coleman

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Purpose: To compare the clinical characteristics of primary open-angle glaucoma (POAG) and pseudoexfoliative glaucoma (PEXG) identified in the Thessaloniki Eye Study and to evaluate the proportion of subjects with and without pseudoexfoliation (PEX) who have glaucoma by screening intraocular pressure (IOP). Design: Cross-sectional, population-based study. Methods: Randomly selected subjects ≥60 years (n = 2,554) participated in the Thessaloniki Eye Study. Subjects were classified as having POAG or PEXG according to specific criteria. POAG and PEXG cases were compared for various clinical characteristics. The proportion with glaucoma among subjects with PEX and the proportion with glaucoma among subjects without PEX were estimated by IOP levels. Results: Among the clinic-visit participants (n = 2,261), 94 subjects (4.2%) had POAG and 41 (1.8%) had PEXG. The prevalence of glaucoma among subjects with PEX was 15.2% and the prevalence of glaucoma among subjects without PEX was 4.7%. In subjects without treatment, the mean IOPs were 19.8 mm Hg and 24.3 mm Hg for POAG and PEXG, respectively. For IOP level >20 mm Hg, the proportion with glaucoma among subjects with PEX was higher than that for glaucoma among subjects without PEX (37% vs 15%; P = .004), while no statistically significant difference was found for IOP level ≤20 mm Hg (2.1% vs 2.1%; P = .999), Fisher exact test. Conclusions: In the Thessaloniki Eye Study, for screening IOP ≤20 mm Hg the proportion with glaucoma was similar in subjects with and without PEX. For IOP level >20 mm Hg, the proportion with glaucoma increased highly in subjects both with and without PEX, while it was much higher among those with PEX at the same screening IOP.

Original languageEnglish
JournalAmerican Journal of Ophthalmology
Volume148
Issue number4
DOIs
StatePublished - Oct 2009

Fingerprint

Intraocular Pressure
Glaucoma
Ambulatory Care
Primary Open Angle Glaucoma

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Increased Likelihood of Glaucoma at the Same Screening Intraocular Pressure in Subjects With Pseudoexfoliation : The Thessaloniki Eye Study. / Topouzis, Fotis; Harris, Alon; Wilson, M. Roy; Koskosas, Archimidis; Founti, Panayiota; Yu, Fei; Anastasopoulos, Eleftherios; Pappas, Theofanis; Coleman, Anne L.

In: American Journal of Ophthalmology, Vol. 148, No. 4, 10.2009.

Research output: Contribution to journalArticle

Topouzis, Fotis ; Harris, Alon ; Wilson, M. Roy ; Koskosas, Archimidis ; Founti, Panayiota ; Yu, Fei ; Anastasopoulos, Eleftherios ; Pappas, Theofanis ; Coleman, Anne L. / Increased Likelihood of Glaucoma at the Same Screening Intraocular Pressure in Subjects With Pseudoexfoliation : The Thessaloniki Eye Study. In: American Journal of Ophthalmology. 2009 ; Vol. 148, No. 4.
@article{716ef7b24e4a41d58872ea6743a2d4f1,
title = "Increased Likelihood of Glaucoma at the Same Screening Intraocular Pressure in Subjects With Pseudoexfoliation: The Thessaloniki Eye Study",
abstract = "Purpose: To compare the clinical characteristics of primary open-angle glaucoma (POAG) and pseudoexfoliative glaucoma (PEXG) identified in the Thessaloniki Eye Study and to evaluate the proportion of subjects with and without pseudoexfoliation (PEX) who have glaucoma by screening intraocular pressure (IOP). Design: Cross-sectional, population-based study. Methods: Randomly selected subjects ≥60 years (n = 2,554) participated in the Thessaloniki Eye Study. Subjects were classified as having POAG or PEXG according to specific criteria. POAG and PEXG cases were compared for various clinical characteristics. The proportion with glaucoma among subjects with PEX and the proportion with glaucoma among subjects without PEX were estimated by IOP levels. Results: Among the clinic-visit participants (n = 2,261), 94 subjects (4.2{\%}) had POAG and 41 (1.8{\%}) had PEXG. The prevalence of glaucoma among subjects with PEX was 15.2{\%} and the prevalence of glaucoma among subjects without PEX was 4.7{\%}. In subjects without treatment, the mean IOPs were 19.8 mm Hg and 24.3 mm Hg for POAG and PEXG, respectively. For IOP level >20 mm Hg, the proportion with glaucoma among subjects with PEX was higher than that for glaucoma among subjects without PEX (37{\%} vs 15{\%}; P = .004), while no statistically significant difference was found for IOP level ≤20 mm Hg (2.1{\%} vs 2.1{\%}; P = .999), Fisher exact test. Conclusions: In the Thessaloniki Eye Study, for screening IOP ≤20 mm Hg the proportion with glaucoma was similar in subjects with and without PEX. For IOP level >20 mm Hg, the proportion with glaucoma increased highly in subjects both with and without PEX, while it was much higher among those with PEX at the same screening IOP.",
author = "Fotis Topouzis and Alon Harris and Wilson, {M. Roy} and Archimidis Koskosas and Panayiota Founti and Fei Yu and Eleftherios Anastasopoulos and Theofanis Pappas and Coleman, {Anne L.}",
year = "2009",
month = "10",
doi = "10.1016/j.ajo.2009.03.024",
language = "English",
volume = "148",
journal = "American Journal of Ophthalmology",
issn = "0002-9394",
publisher = "Elsevier USA",
number = "4",

}

TY - JOUR

T1 - Increased Likelihood of Glaucoma at the Same Screening Intraocular Pressure in Subjects With Pseudoexfoliation

T2 - The Thessaloniki Eye Study

AU - Topouzis, Fotis

AU - Harris, Alon

AU - Wilson, M. Roy

AU - Koskosas, Archimidis

AU - Founti, Panayiota

AU - Yu, Fei

AU - Anastasopoulos, Eleftherios

AU - Pappas, Theofanis

AU - Coleman, Anne L.

PY - 2009/10

Y1 - 2009/10

N2 - Purpose: To compare the clinical characteristics of primary open-angle glaucoma (POAG) and pseudoexfoliative glaucoma (PEXG) identified in the Thessaloniki Eye Study and to evaluate the proportion of subjects with and without pseudoexfoliation (PEX) who have glaucoma by screening intraocular pressure (IOP). Design: Cross-sectional, population-based study. Methods: Randomly selected subjects ≥60 years (n = 2,554) participated in the Thessaloniki Eye Study. Subjects were classified as having POAG or PEXG according to specific criteria. POAG and PEXG cases were compared for various clinical characteristics. The proportion with glaucoma among subjects with PEX and the proportion with glaucoma among subjects without PEX were estimated by IOP levels. Results: Among the clinic-visit participants (n = 2,261), 94 subjects (4.2%) had POAG and 41 (1.8%) had PEXG. The prevalence of glaucoma among subjects with PEX was 15.2% and the prevalence of glaucoma among subjects without PEX was 4.7%. In subjects without treatment, the mean IOPs were 19.8 mm Hg and 24.3 mm Hg for POAG and PEXG, respectively. For IOP level >20 mm Hg, the proportion with glaucoma among subjects with PEX was higher than that for glaucoma among subjects without PEX (37% vs 15%; P = .004), while no statistically significant difference was found for IOP level ≤20 mm Hg (2.1% vs 2.1%; P = .999), Fisher exact test. Conclusions: In the Thessaloniki Eye Study, for screening IOP ≤20 mm Hg the proportion with glaucoma was similar in subjects with and without PEX. For IOP level >20 mm Hg, the proportion with glaucoma increased highly in subjects both with and without PEX, while it was much higher among those with PEX at the same screening IOP.

AB - Purpose: To compare the clinical characteristics of primary open-angle glaucoma (POAG) and pseudoexfoliative glaucoma (PEXG) identified in the Thessaloniki Eye Study and to evaluate the proportion of subjects with and without pseudoexfoliation (PEX) who have glaucoma by screening intraocular pressure (IOP). Design: Cross-sectional, population-based study. Methods: Randomly selected subjects ≥60 years (n = 2,554) participated in the Thessaloniki Eye Study. Subjects were classified as having POAG or PEXG according to specific criteria. POAG and PEXG cases were compared for various clinical characteristics. The proportion with glaucoma among subjects with PEX and the proportion with glaucoma among subjects without PEX were estimated by IOP levels. Results: Among the clinic-visit participants (n = 2,261), 94 subjects (4.2%) had POAG and 41 (1.8%) had PEXG. The prevalence of glaucoma among subjects with PEX was 15.2% and the prevalence of glaucoma among subjects without PEX was 4.7%. In subjects without treatment, the mean IOPs were 19.8 mm Hg and 24.3 mm Hg for POAG and PEXG, respectively. For IOP level >20 mm Hg, the proportion with glaucoma among subjects with PEX was higher than that for glaucoma among subjects without PEX (37% vs 15%; P = .004), while no statistically significant difference was found for IOP level ≤20 mm Hg (2.1% vs 2.1%; P = .999), Fisher exact test. Conclusions: In the Thessaloniki Eye Study, for screening IOP ≤20 mm Hg the proportion with glaucoma was similar in subjects with and without PEX. For IOP level >20 mm Hg, the proportion with glaucoma increased highly in subjects both with and without PEX, while it was much higher among those with PEX at the same screening IOP.

UR - http://www.scopus.com/inward/record.url?scp=70349266000&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70349266000&partnerID=8YFLogxK

U2 - 10.1016/j.ajo.2009.03.024

DO - 10.1016/j.ajo.2009.03.024

M3 - Article

VL - 148

JO - American Journal of Ophthalmology

JF - American Journal of Ophthalmology

SN - 0002-9394

IS - 4

ER -