Increased nucleoside concentrations in tumors as markers of tiazofurin action

Hiremagalur N. Jayaram, Konrad Pillwein, George Weber

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Tiazofurin injection (150 mg/kg, i.p.) into rats bearing hepatoma 3924A increased in the tumor the pools of guanine, uridine, thymine, hypoxanthine, inosine, and thymidine 3.5-, 4.4-, 8.0- 18.4-, 18.7- and 42-fold over the controls. There were only minor changes in the host liver. This is the first report showing a selective action of tiazofurin in cancer cells on the concentrations of nucleosides and bases, indicating that these might be used as markers of the impact of tiazofurin in clinical trials.

Original languageEnglish (US)
Pages (from-to)503-509
Number of pages7
JournalNucleosides and Nucleotides
Volume5
Issue number5
DOIs
StatePublished - Dec 1 1986

ASJC Scopus subject areas

  • Biochemistry
  • Genetics

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