Increased temporal variability of auditory event-related potentials in schizophrenia and Schizotypal Personality Disorder

Yong Wook Shin, Giri Krishnan, William P. Hetrick, Colleen A. Brenner, Anantha Shekhar, Frederick W. Malloy, Brian O'Donnell

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Previous studies suggest that deficits in neural synchronization and temporal integration are characteristic of schizophrenia. These phenomena have been rarely studied in SPD, which shares phenomenological and genetic similarities with schizophrenia. Event-related potentials (ERPs) were obtained using an auditory oddball task from 21 patients with schizophrenia, 19 subjects with SPD and 19 healthy control subjects. Inter-trial coherence (ITC) and event-related spectral perturbation (ERSP) were measured across trials to target tones using time-frequency analysis. ITC measures phase locking or consistency, while ERSP measures changes in power relative to baseline activity. P300 latency and amplitude were also measured from the averaged ERP to target tones. In the time-frequency analysis, subjects with SPD showed intact power but a deficit in the ITC in delta and theta frequencies compared to control subjects. Patients with schizophrenia showed deficits for both ERSP and ITC in the delta and theta frequencies. While patients with schizophrenia showed reduced P300 amplitude and delayed latency for averaged ERPs, subjects with SPD did not differ from either group. Synchronization or timing abnormalities may represent a biomarker for schizophrenia spectrum disorders, and contribute to aberrant perceptual and cognitive integration.

Original languageEnglish
Pages (from-to)110-118
Number of pages9
JournalSchizophrenia Research
Volume124
Issue number1-3
DOIs
StatePublished - Dec 2010

Fingerprint

Schizotypal Personality Disorder
Evoked Potentials
Schizophrenia
Healthy Volunteers
Biomarkers

Keywords

  • Auditory event-related potentials
  • Schizophrenia
  • Schizotypal Personality Disorder
  • Synchronization
  • Time frequency analysis

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Increased temporal variability of auditory event-related potentials in schizophrenia and Schizotypal Personality Disorder. / Shin, Yong Wook; Krishnan, Giri; Hetrick, William P.; Brenner, Colleen A.; Shekhar, Anantha; Malloy, Frederick W.; O'Donnell, Brian.

In: Schizophrenia Research, Vol. 124, No. 1-3, 12.2010, p. 110-118.

Research output: Contribution to journalArticle

Shin, Yong Wook ; Krishnan, Giri ; Hetrick, William P. ; Brenner, Colleen A. ; Shekhar, Anantha ; Malloy, Frederick W. ; O'Donnell, Brian. / Increased temporal variability of auditory event-related potentials in schizophrenia and Schizotypal Personality Disorder. In: Schizophrenia Research. 2010 ; Vol. 124, No. 1-3. pp. 110-118.
@article{25006a41e9c64cb88e1353c45627d5dc,
title = "Increased temporal variability of auditory event-related potentials in schizophrenia and Schizotypal Personality Disorder",
abstract = "Previous studies suggest that deficits in neural synchronization and temporal integration are characteristic of schizophrenia. These phenomena have been rarely studied in SPD, which shares phenomenological and genetic similarities with schizophrenia. Event-related potentials (ERPs) were obtained using an auditory oddball task from 21 patients with schizophrenia, 19 subjects with SPD and 19 healthy control subjects. Inter-trial coherence (ITC) and event-related spectral perturbation (ERSP) were measured across trials to target tones using time-frequency analysis. ITC measures phase locking or consistency, while ERSP measures changes in power relative to baseline activity. P300 latency and amplitude were also measured from the averaged ERP to target tones. In the time-frequency analysis, subjects with SPD showed intact power but a deficit in the ITC in delta and theta frequencies compared to control subjects. Patients with schizophrenia showed deficits for both ERSP and ITC in the delta and theta frequencies. While patients with schizophrenia showed reduced P300 amplitude and delayed latency for averaged ERPs, subjects with SPD did not differ from either group. Synchronization or timing abnormalities may represent a biomarker for schizophrenia spectrum disorders, and contribute to aberrant perceptual and cognitive integration.",
keywords = "Auditory event-related potentials, Schizophrenia, Schizotypal Personality Disorder, Synchronization, Time frequency analysis",
author = "Shin, {Yong Wook} and Giri Krishnan and Hetrick, {William P.} and Brenner, {Colleen A.} and Anantha Shekhar and Malloy, {Frederick W.} and Brian O'Donnell",
year = "2010",
month = "12",
doi = "10.1016/j.schres.2010.08.008",
language = "English",
volume = "124",
pages = "110--118",
journal = "Schizophrenia Research",
issn = "0920-9964",
publisher = "Elsevier",
number = "1-3",

}

TY - JOUR

T1 - Increased temporal variability of auditory event-related potentials in schizophrenia and Schizotypal Personality Disorder

AU - Shin, Yong Wook

AU - Krishnan, Giri

AU - Hetrick, William P.

AU - Brenner, Colleen A.

AU - Shekhar, Anantha

AU - Malloy, Frederick W.

AU - O'Donnell, Brian

PY - 2010/12

Y1 - 2010/12

N2 - Previous studies suggest that deficits in neural synchronization and temporal integration are characteristic of schizophrenia. These phenomena have been rarely studied in SPD, which shares phenomenological and genetic similarities with schizophrenia. Event-related potentials (ERPs) were obtained using an auditory oddball task from 21 patients with schizophrenia, 19 subjects with SPD and 19 healthy control subjects. Inter-trial coherence (ITC) and event-related spectral perturbation (ERSP) were measured across trials to target tones using time-frequency analysis. ITC measures phase locking or consistency, while ERSP measures changes in power relative to baseline activity. P300 latency and amplitude were also measured from the averaged ERP to target tones. In the time-frequency analysis, subjects with SPD showed intact power but a deficit in the ITC in delta and theta frequencies compared to control subjects. Patients with schizophrenia showed deficits for both ERSP and ITC in the delta and theta frequencies. While patients with schizophrenia showed reduced P300 amplitude and delayed latency for averaged ERPs, subjects with SPD did not differ from either group. Synchronization or timing abnormalities may represent a biomarker for schizophrenia spectrum disorders, and contribute to aberrant perceptual and cognitive integration.

AB - Previous studies suggest that deficits in neural synchronization and temporal integration are characteristic of schizophrenia. These phenomena have been rarely studied in SPD, which shares phenomenological and genetic similarities with schizophrenia. Event-related potentials (ERPs) were obtained using an auditory oddball task from 21 patients with schizophrenia, 19 subjects with SPD and 19 healthy control subjects. Inter-trial coherence (ITC) and event-related spectral perturbation (ERSP) were measured across trials to target tones using time-frequency analysis. ITC measures phase locking or consistency, while ERSP measures changes in power relative to baseline activity. P300 latency and amplitude were also measured from the averaged ERP to target tones. In the time-frequency analysis, subjects with SPD showed intact power but a deficit in the ITC in delta and theta frequencies compared to control subjects. Patients with schizophrenia showed deficits for both ERSP and ITC in the delta and theta frequencies. While patients with schizophrenia showed reduced P300 amplitude and delayed latency for averaged ERPs, subjects with SPD did not differ from either group. Synchronization or timing abnormalities may represent a biomarker for schizophrenia spectrum disorders, and contribute to aberrant perceptual and cognitive integration.

KW - Auditory event-related potentials

KW - Schizophrenia

KW - Schizotypal Personality Disorder

KW - Synchronization

KW - Time frequency analysis

UR - http://www.scopus.com/inward/record.url?scp=78249261166&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78249261166&partnerID=8YFLogxK

U2 - 10.1016/j.schres.2010.08.008

DO - 10.1016/j.schres.2010.08.008

M3 - Article

C2 - 20817485

AN - SCOPUS:78249261166

VL - 124

SP - 110

EP - 118

JO - Schizophrenia Research

JF - Schizophrenia Research

SN - 0920-9964

IS - 1-3

ER -