Increased temporal variability of auditory event-related potentials in schizophrenia and Schizotypal Personality Disorder

Yong Wook Shin, Giri Krishnan, William P. Hetrick, Colleen A. Brenner, Anantha Shekhar, Frederick W. Malloy, Brian F. O'donnell

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Previous studies suggest that deficits in neural synchronization and temporal integration are characteristic of schizophrenia. These phenomena have been rarely studied in SPD, which shares phenomenological and genetic similarities with schizophrenia. Event-related potentials (ERPs) were obtained using an auditory oddball task from 21 patients with schizophrenia, 19 subjects with SPD and 19 healthy control subjects. Inter-trial coherence (ITC) and event-related spectral perturbation (ERSP) were measured across trials to target tones using time-frequency analysis. ITC measures phase locking or consistency, while ERSP measures changes in power relative to baseline activity. P300 latency and amplitude were also measured from the averaged ERP to target tones. In the time-frequency analysis, subjects with SPD showed intact power but a deficit in the ITC in delta and theta frequencies compared to control subjects. Patients with schizophrenia showed deficits for both ERSP and ITC in the delta and theta frequencies. While patients with schizophrenia showed reduced P300 amplitude and delayed latency for averaged ERPs, subjects with SPD did not differ from either group. Synchronization or timing abnormalities may represent a biomarker for schizophrenia spectrum disorders, and contribute to aberrant perceptual and cognitive integration.

Original languageEnglish (US)
Pages (from-to)110-118
Number of pages9
JournalSchizophrenia Research
Issue number1-3
StatePublished - Dec 2010


  • Auditory event-related potentials
  • Schizophrenia
  • Schizotypal Personality Disorder
  • Synchronization
  • Time frequency analysis

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Fingerprint Dive into the research topics of 'Increased temporal variability of auditory event-related potentials in schizophrenia and Schizotypal Personality Disorder'. Together they form a unique fingerprint.

Cite this