Increased timing variability in schizophrenia and bipolar disorder

Amanda R. Bolbecker, Daniel R. Westfall, Josselyn M. Howell, Ryan J. Lackner, Christine A. Carroll, Brian O'Donnell, William P. Hetrick

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Theoretical and empirical evidence suggests that impaired time perception and the neural circuitry underlying internal timing mechanisms may contribute to severe psychiatric disorders, including psychotic and mood disorders. The degree to which alterations in temporal perceptions reflect deficits that exist across psychosis-related phenotypes and the extent to which mood symptoms contribute to these deficits is currently unknown. In addition, compared to schizophrenia, where timing deficits have been more extensively investigated, sub-second timing has been studied relatively infrequently in bipolar disorder. The present study compared sub-second duration estimates of schizophrenia (SZ), schizoaffective disorder (SA), non-psychotic bipolar disorder (BDNP), bipolar disorder with psychotic features (BDP), and healthy non-psychiatric controls (HC) on a well-established time perception task using sub-second durations. Participants included 66 SZ, 37 BDNP, 34 BDP, 31 SA, and 73 HC who participated in a temporal bisection task that required temporal judgements about auditory durations ranging from 300 to 600 milliseconds. Timing variability was significantly higher in SZ, BDP, and BDNP groups compared to healthy controls. The bisection point did not differ across groups. These findings suggest that both psychotic and mood symptoms may be associated with disruptions in internal timing mechanisms. Yet unexpected findings emerged. Specifically, the BDNP group had significantly increased variability compared to controls, but the SA group did not. In addition, these deficits appeared to exist independent of current symptom status. The absence of between group differences in bisection point suggests that increased variability in the SZ and bipolar disorder groups are due to alterations in perceptual timing in the sub-second range, possibly mediated by the cerebellum, rather than cognitive deficits.

Original languageEnglish
Article numbere97964
JournalPLoS One
Volume9
Issue number5
DOIs
StatePublished - May 21 2014

Fingerprint

Bipolar Disorder
Schizophrenia
Time Perception
Psychotic Disorders
emotions
duration
Psychotic Affective Disorders
behavior disorders
cerebellum
Cerebellum
Psychiatry
schizophrenia
N,N'-bis(1-decylnipecotoyl)piperazine
Phenotype
phenotype

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Bolbecker, A. R., Westfall, D. R., Howell, J. M., Lackner, R. J., Carroll, C. A., O'Donnell, B., & Hetrick, W. P. (2014). Increased timing variability in schizophrenia and bipolar disorder. PLoS One, 9(5), [e97964]. https://doi.org/10.1371/journal.pone.0097964

Increased timing variability in schizophrenia and bipolar disorder. / Bolbecker, Amanda R.; Westfall, Daniel R.; Howell, Josselyn M.; Lackner, Ryan J.; Carroll, Christine A.; O'Donnell, Brian; Hetrick, William P.

In: PLoS One, Vol. 9, No. 5, e97964, 21.05.2014.

Research output: Contribution to journalArticle

Bolbecker, AR, Westfall, DR, Howell, JM, Lackner, RJ, Carroll, CA, O'Donnell, B & Hetrick, WP 2014, 'Increased timing variability in schizophrenia and bipolar disorder', PLoS One, vol. 9, no. 5, e97964. https://doi.org/10.1371/journal.pone.0097964
Bolbecker AR, Westfall DR, Howell JM, Lackner RJ, Carroll CA, O'Donnell B et al. Increased timing variability in schizophrenia and bipolar disorder. PLoS One. 2014 May 21;9(5). e97964. https://doi.org/10.1371/journal.pone.0097964
Bolbecker, Amanda R. ; Westfall, Daniel R. ; Howell, Josselyn M. ; Lackner, Ryan J. ; Carroll, Christine A. ; O'Donnell, Brian ; Hetrick, William P. / Increased timing variability in schizophrenia and bipolar disorder. In: PLoS One. 2014 ; Vol. 9, No. 5.
@article{5849cc9664de4500affe0ad75fab3f4c,
title = "Increased timing variability in schizophrenia and bipolar disorder",
abstract = "Theoretical and empirical evidence suggests that impaired time perception and the neural circuitry underlying internal timing mechanisms may contribute to severe psychiatric disorders, including psychotic and mood disorders. The degree to which alterations in temporal perceptions reflect deficits that exist across psychosis-related phenotypes and the extent to which mood symptoms contribute to these deficits is currently unknown. In addition, compared to schizophrenia, where timing deficits have been more extensively investigated, sub-second timing has been studied relatively infrequently in bipolar disorder. The present study compared sub-second duration estimates of schizophrenia (SZ), schizoaffective disorder (SA), non-psychotic bipolar disorder (BDNP), bipolar disorder with psychotic features (BDP), and healthy non-psychiatric controls (HC) on a well-established time perception task using sub-second durations. Participants included 66 SZ, 37 BDNP, 34 BDP, 31 SA, and 73 HC who participated in a temporal bisection task that required temporal judgements about auditory durations ranging from 300 to 600 milliseconds. Timing variability was significantly higher in SZ, BDP, and BDNP groups compared to healthy controls. The bisection point did not differ across groups. These findings suggest that both psychotic and mood symptoms may be associated with disruptions in internal timing mechanisms. Yet unexpected findings emerged. Specifically, the BDNP group had significantly increased variability compared to controls, but the SA group did not. In addition, these deficits appeared to exist independent of current symptom status. The absence of between group differences in bisection point suggests that increased variability in the SZ and bipolar disorder groups are due to alterations in perceptual timing in the sub-second range, possibly mediated by the cerebellum, rather than cognitive deficits.",
author = "Bolbecker, {Amanda R.} and Westfall, {Daniel R.} and Howell, {Josselyn M.} and Lackner, {Ryan J.} and Carroll, {Christine A.} and Brian O'Donnell and Hetrick, {William P.}",
year = "2014",
month = "5",
day = "21",
doi = "10.1371/journal.pone.0097964",
language = "English",
volume = "9",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "5",

}

TY - JOUR

T1 - Increased timing variability in schizophrenia and bipolar disorder

AU - Bolbecker, Amanda R.

AU - Westfall, Daniel R.

AU - Howell, Josselyn M.

AU - Lackner, Ryan J.

AU - Carroll, Christine A.

AU - O'Donnell, Brian

AU - Hetrick, William P.

PY - 2014/5/21

Y1 - 2014/5/21

N2 - Theoretical and empirical evidence suggests that impaired time perception and the neural circuitry underlying internal timing mechanisms may contribute to severe psychiatric disorders, including psychotic and mood disorders. The degree to which alterations in temporal perceptions reflect deficits that exist across psychosis-related phenotypes and the extent to which mood symptoms contribute to these deficits is currently unknown. In addition, compared to schizophrenia, where timing deficits have been more extensively investigated, sub-second timing has been studied relatively infrequently in bipolar disorder. The present study compared sub-second duration estimates of schizophrenia (SZ), schizoaffective disorder (SA), non-psychotic bipolar disorder (BDNP), bipolar disorder with psychotic features (BDP), and healthy non-psychiatric controls (HC) on a well-established time perception task using sub-second durations. Participants included 66 SZ, 37 BDNP, 34 BDP, 31 SA, and 73 HC who participated in a temporal bisection task that required temporal judgements about auditory durations ranging from 300 to 600 milliseconds. Timing variability was significantly higher in SZ, BDP, and BDNP groups compared to healthy controls. The bisection point did not differ across groups. These findings suggest that both psychotic and mood symptoms may be associated with disruptions in internal timing mechanisms. Yet unexpected findings emerged. Specifically, the BDNP group had significantly increased variability compared to controls, but the SA group did not. In addition, these deficits appeared to exist independent of current symptom status. The absence of between group differences in bisection point suggests that increased variability in the SZ and bipolar disorder groups are due to alterations in perceptual timing in the sub-second range, possibly mediated by the cerebellum, rather than cognitive deficits.

AB - Theoretical and empirical evidence suggests that impaired time perception and the neural circuitry underlying internal timing mechanisms may contribute to severe psychiatric disorders, including psychotic and mood disorders. The degree to which alterations in temporal perceptions reflect deficits that exist across psychosis-related phenotypes and the extent to which mood symptoms contribute to these deficits is currently unknown. In addition, compared to schizophrenia, where timing deficits have been more extensively investigated, sub-second timing has been studied relatively infrequently in bipolar disorder. The present study compared sub-second duration estimates of schizophrenia (SZ), schizoaffective disorder (SA), non-psychotic bipolar disorder (BDNP), bipolar disorder with psychotic features (BDP), and healthy non-psychiatric controls (HC) on a well-established time perception task using sub-second durations. Participants included 66 SZ, 37 BDNP, 34 BDP, 31 SA, and 73 HC who participated in a temporal bisection task that required temporal judgements about auditory durations ranging from 300 to 600 milliseconds. Timing variability was significantly higher in SZ, BDP, and BDNP groups compared to healthy controls. The bisection point did not differ across groups. These findings suggest that both psychotic and mood symptoms may be associated with disruptions in internal timing mechanisms. Yet unexpected findings emerged. Specifically, the BDNP group had significantly increased variability compared to controls, but the SA group did not. In addition, these deficits appeared to exist independent of current symptom status. The absence of between group differences in bisection point suggests that increased variability in the SZ and bipolar disorder groups are due to alterations in perceptual timing in the sub-second range, possibly mediated by the cerebellum, rather than cognitive deficits.

UR - http://www.scopus.com/inward/record.url?scp=84901362886&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84901362886&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0097964

DO - 10.1371/journal.pone.0097964

M3 - Article

VL - 9

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 5

M1 - e97964

ER -