Increased wave break during ventricular fibrillation in the epicardial border zone of hearts with healed myocardial infarction

Toshihiko Ohara, Keiko Ohara, Ji Min Cao, Moon Hyoung Lee, Michael C. Fishbein, William J. Mandel, Peng-Sheng Chen, Hrayr S. Karagueuzian

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Background - The action potential duration (APD) restitution hypothesis of wave break during ventricular fibrillation (VF) in the epicardial border zone (EBZ) of hearts with chronic myocardial infarction is unknown. Methods and Results - VF was induced by rapid pacing, and the EBZ with the two adjoining sites (right ventricle and lateral left ventricle) were sequentially mapped in random order in 7 open-chest anesthetized dogs 6 to 8 weeks after left anterior descending artery occlusion and in 4 control dogs. At each site, 3 seconds of VF was mapped with 477 bipolar electrodes 1.6 mm apart. The number of wave fronts and approximate entropy were significantly (P 1. Connexin43-positive staining was significantly (P

Original languageEnglish (US)
Pages (from-to)1465-1472
Number of pages8
JournalCirculation
Volume103
Issue number10
StatePublished - Mar 13 2001
Externally publishedYes

Fingerprint

Ventricular Fibrillation
Myocardial Infarction
Heart Ventricles
Dogs
Connexin 43
Lateral Ventricles
Entropy
Action Potentials
Electrodes
Thorax
Arteries
Staining and Labeling

Keywords

  • Action potentials
  • Fibrillation
  • Myocardial infarction
  • Waves

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Ohara, T., Ohara, K., Cao, J. M., Lee, M. H., Fishbein, M. C., Mandel, W. J., ... Karagueuzian, H. S. (2001). Increased wave break during ventricular fibrillation in the epicardial border zone of hearts with healed myocardial infarction. Circulation, 103(10), 1465-1472.

Increased wave break during ventricular fibrillation in the epicardial border zone of hearts with healed myocardial infarction. / Ohara, Toshihiko; Ohara, Keiko; Cao, Ji Min; Lee, Moon Hyoung; Fishbein, Michael C.; Mandel, William J.; Chen, Peng-Sheng; Karagueuzian, Hrayr S.

In: Circulation, Vol. 103, No. 10, 13.03.2001, p. 1465-1472.

Research output: Contribution to journalArticle

Ohara, T, Ohara, K, Cao, JM, Lee, MH, Fishbein, MC, Mandel, WJ, Chen, P-S & Karagueuzian, HS 2001, 'Increased wave break during ventricular fibrillation in the epicardial border zone of hearts with healed myocardial infarction', Circulation, vol. 103, no. 10, pp. 1465-1472.
Ohara T, Ohara K, Cao JM, Lee MH, Fishbein MC, Mandel WJ et al. Increased wave break during ventricular fibrillation in the epicardial border zone of hearts with healed myocardial infarction. Circulation. 2001 Mar 13;103(10):1465-1472.
Ohara, Toshihiko ; Ohara, Keiko ; Cao, Ji Min ; Lee, Moon Hyoung ; Fishbein, Michael C. ; Mandel, William J. ; Chen, Peng-Sheng ; Karagueuzian, Hrayr S. / Increased wave break during ventricular fibrillation in the epicardial border zone of hearts with healed myocardial infarction. In: Circulation. 2001 ; Vol. 103, No. 10. pp. 1465-1472.
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