Independent influence of dietary protein on markers of kidney function and disease in obesity

Allon N. Friedman, Zhangsheng Yu, Beth E. Juliar, James T. Nguyen, Matthew Strother, Sara K. Quinney, Lang Li, Margaret Inman, Gerardo Gomez, Zak Shihabi, Sharon Moe

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Obesity is associated with glomerular hyperfiltration and increased urinary protein excretion, as well as structural and functional changes that lead to kidney disease and failure. Dietary protein mimics obesity's effects on the glomerular filtration rate (GFR) and proteinuria and, in certain circumstances, may have the potential to adversely affect kidney function. Here we tested the hypothesis that dietary protein independently explains elevations in the GFR and proteinuria found in obese persons with a normal serum creatinine. Seventeen patients were randomized in a double-blind, crossover fashion for 1-week periods to high (140 g/day) and low (50 g/day) protein diets with a 1-week washout interval separating these periods. High protein consumption was associated with a very modest but significant increase in the GFR of 56 ml/min. Hence, while dietary protein does modulate kidney parameters, it is unlikely to fully account for the elevations in GFR and proteinuria found in obesity.

Original languageEnglish (US)
Pages (from-to)693-697
Number of pages5
JournalKidney international
Volume78
Issue number7
DOIs
StatePublished - Oct 2010

Keywords

  • albuminuria
  • glomerular filtration rate
  • nutrition
  • obesity
  • proteinuria

ASJC Scopus subject areas

  • Nephrology

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