Indeterminate pulmonary nodules in patients with sarcoma affect survival

Stacy Rissing, Bruce T. Rougraff, Kenneth Davis

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18 Scopus citations

Abstract

We prospectively studied 331 sarcoma patients treated between April 1999 and December 2004 to see if small, indeterminate pulmonary nodules are of prognostic significance. Seventy-one (21%) had indeterminate pulmonary nodules on initial spiral CCT. Twenty of 71 (28%) patients with indeterminate nodules progressed with metastatic disease. Metastatic disease developed in 18/20 (90%) in the area of the original indeterminate nodule. The presence of tiny (<5 mm) indeterminate nodules was not a prognostic variable, however, the presence of nodules ≥5 mm was associated with worse 3 year disease-free survival compared to those with no nodules or tiny nodules (81% versus 49%) but better than those with definite metastatic disease at presentation (49% versus 5%). Because patients with pulmonary nodules ≥5 mm are at increased risk for metastatic disease compared to patients with normal CCT or those with <5 mm nodules but better survival than patients with Stage IV disease, we believe a new staging system of these patients should be considered and recommend careful followup.

Original languageEnglish (US)
Pages (from-to)118-121
Number of pages4
JournalClinical Orthopaedics and Related Research
Issue number459
DOIs
StatePublished - Jun 2007

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ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

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