Abstract
Indiana University's kidney transplant program has undergone changes in the program's approach to immunosuppression. This change in philosophy has moved the program away from multiple chronic maintenance immunosuppression strategies with corticosteroids to steroid-free maintenance immunosuppressive strategies for both adults and pediatric recipients. Anti-thymocyte globulin induction (beginning pre-reperfusion) has allowed for the rapid post-transplant withdrawal of corticosteroids. Steroid-free maintenance immunosuppression has been achieved with excellent patient and graft survival as well as lower rejection rates in the first posttransplant year. Desensitized recipients can also be safely included in steroid-free protocols. The administration of anti-thymocyte globulin prereperfusion combined with pulsatile perfusion storage of deceased donor kidneys has led to an extremely low delayed graft function rate.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 135-142 |
| Number of pages | 8 |
| Journal | Clinical transplants |
| State | Published - 2009 |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
Indiana University kidney transplant program : overview and summary of the last 1022 kidney alone transplants with at least 1 year follow-up. / Goggins, William; Powelson, John; Fridell, Jonathan; Mishler, Dennis; Yaqub, Muhammad; Chen, Jeanne; Sharfuddin, Asif; Taber, Tim; Milgrom, Martin.
In: Clinical transplants, 2009, p. 135-142.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Indiana University kidney transplant program
T2 - overview and summary of the last 1022 kidney alone transplants with at least 1 year follow-up.
AU - Goggins, William
AU - Powelson, John
AU - Fridell, Jonathan
AU - Mishler, Dennis
AU - Yaqub, Muhammad
AU - Chen, Jeanne
AU - Sharfuddin, Asif
AU - Taber, Tim
AU - Milgrom, Martin
PY - 2009
Y1 - 2009
N2 - Indiana University's kidney transplant program has undergone changes in the program's approach to immunosuppression. This change in philosophy has moved the program away from multiple chronic maintenance immunosuppression strategies with corticosteroids to steroid-free maintenance immunosuppressive strategies for both adults and pediatric recipients. Anti-thymocyte globulin induction (beginning pre-reperfusion) has allowed for the rapid post-transplant withdrawal of corticosteroids. Steroid-free maintenance immunosuppression has been achieved with excellent patient and graft survival as well as lower rejection rates in the first posttransplant year. Desensitized recipients can also be safely included in steroid-free protocols. The administration of anti-thymocyte globulin prereperfusion combined with pulsatile perfusion storage of deceased donor kidneys has led to an extremely low delayed graft function rate.
AB - Indiana University's kidney transplant program has undergone changes in the program's approach to immunosuppression. This change in philosophy has moved the program away from multiple chronic maintenance immunosuppression strategies with corticosteroids to steroid-free maintenance immunosuppressive strategies for both adults and pediatric recipients. Anti-thymocyte globulin induction (beginning pre-reperfusion) has allowed for the rapid post-transplant withdrawal of corticosteroids. Steroid-free maintenance immunosuppression has been achieved with excellent patient and graft survival as well as lower rejection rates in the first posttransplant year. Desensitized recipients can also be safely included in steroid-free protocols. The administration of anti-thymocyte globulin prereperfusion combined with pulsatile perfusion storage of deceased donor kidneys has led to an extremely low delayed graft function rate.
UR - http://www.scopus.com/inward/record.url?scp=77954601190&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77954601190&partnerID=8YFLogxK
M3 - Article
C2 - 20524281
AN - SCOPUS:77954601190
SP - 135
EP - 142
JO - Clinical transplants
JF - Clinical transplants
SN - 0890-9016
ER -