Induction of autoimmunity after allotransplantation

Gilles Benichou, Alessandro Alessandrini, Rachida Sihem Charrad, David S. Wilkes

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Our studies show that activated autoreactive inflammatory T cells specific and autoantibodies to collagen (V) and cardiac myosin are consistently detected after lung and heart transplantation, respectively. Clonal expansion of these T cells occurs only after an alloresponse, but once activated they can induce on their own rejection of allogeneic and even syngeneic transplants. Indirect rather than indirect alloresponse triggers autoimmunity after transplantation presumably via antigen mimicry between autoantigen peptides and donor MHC peptides. Also, it is plausible that inflammation and tissue damage associated with initial alloresponse to donor MHC antigens causes the release of formerly sequestered autoantigens. This may result in the presentation of some cryptic self-determinants thereby triggering an autoimmune process at the site of the graft. Finally, tolerance induction to cardiac myosin and collagen (V) results in long-term survival and reduced pathogenesis of heart and lung allografts, respectively. This suggests that, after transplantation, the inflammatory alloresponse to donor MHC triggers a cascade of events including autoimmunity to tissue antigens, a phenomenon that is essential to the actual rejection.

Original languageEnglish
Pages (from-to)4362-4369
Number of pages8
JournalFrontiers in Bioscience
Volume12
Issue number11
DOIs
StatePublished - May 1 2007

Fingerprint

Cardiac Myosins
Autoantigens
Autoimmunity
Collagen
T-cells
Myosin Type V
Transplantation
Heart-Lung Transplantation
Molecular Mimicry
T-Lymphocytes
Transplants
Antigens
Peptides
Autoantibodies
Tissue
Allografts
Inflammation
Grafts
Lung

Keywords

  • Allorecognition
  • Autoimmune disease
  • Heart
  • Lung
  • Review
  • T cells
  • Transplantation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)

Cite this

Benichou, G., Alessandrini, A., Charrad, R. S., & Wilkes, D. S. (2007). Induction of autoimmunity after allotransplantation. Frontiers in Bioscience, 12(11), 4362-4369. https://doi.org/10.2741/2393

Induction of autoimmunity after allotransplantation. / Benichou, Gilles; Alessandrini, Alessandro; Charrad, Rachida Sihem; Wilkes, David S.

In: Frontiers in Bioscience, Vol. 12, No. 11, 01.05.2007, p. 4362-4369.

Research output: Contribution to journalArticle

Benichou, G, Alessandrini, A, Charrad, RS & Wilkes, DS 2007, 'Induction of autoimmunity after allotransplantation', Frontiers in Bioscience, vol. 12, no. 11, pp. 4362-4369. https://doi.org/10.2741/2393
Benichou G, Alessandrini A, Charrad RS, Wilkes DS. Induction of autoimmunity after allotransplantation. Frontiers in Bioscience. 2007 May 1;12(11):4362-4369. https://doi.org/10.2741/2393
Benichou, Gilles ; Alessandrini, Alessandro ; Charrad, Rachida Sihem ; Wilkes, David S. / Induction of autoimmunity after allotransplantation. In: Frontiers in Bioscience. 2007 ; Vol. 12, No. 11. pp. 4362-4369.
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