Induction of dependence on ethanol by free-choice drinking in alcohol-preferring rats

M. B. Waller, W. J. McBride, L. Lumeng, T. K. Li

Research output: Contribution to journalArticle

161 Citations (Scopus)

Abstract

Studies were performed to examine whether chronic, voluntary consumption of ethanol by the selectively-bred, alcohol-preferring P-rats produces physical dependence. Body weight reduction, food restriction and flavoring the 10% ethanol solution increased ethanol consumption from 7 to 14 g ethanol/kg body weight/day when water was freely available. Under similar conditions, consumption by selectively-bred, alcohol-nonpreferring NP-rats increased from 1 to 12 g/kg/day. Removal of ethanol after eight weeks induced physical signs of withdrawal in both lines of animals. In two subsequent studies, P-rats were given food, water and unflavored 10% ethanol ad lib for 15 and 20 weeks; ethanol consumption was 7.2 and 5.6 g/kg/day, respectively. Upon removal of ethanol, manifestations of withdrawal, scored blind in one experiment, developed in 85% of the animals and persisted for 72 hours. Importantly, none in the control groups of P and NP rats given water only exhibited these signs. The ethanol withdrawn groups were hyperactive in both the open-field and the head-poke apparatus. These results indicate that sufficient ethanol was voluntarily consumed by the selectively-bred alcohol-preferring P-rats under free-feeding conditions to produce physical dependence.

Original languageEnglish
Pages (from-to)501-507
Number of pages7
JournalPharmacology Biochemistry and Behavior
Volume16
Issue number3
DOIs
StatePublished - 1982

Fingerprint

Alcohol Drinking
Rats
Ethanol
Alcohols
Water
Animals
Body Weight
Food
Weight Loss
Head
Control Groups

Keywords

  • Alcohol-preferring rats
  • Ethanol
  • Oral ethanol consumption
  • Physical dependence
  • Withdrawal syndrome

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

Induction of dependence on ethanol by free-choice drinking in alcohol-preferring rats. / Waller, M. B.; McBride, W. J.; Lumeng, L.; Li, T. K.

In: Pharmacology Biochemistry and Behavior, Vol. 16, No. 3, 1982, p. 501-507.

Research output: Contribution to journalArticle

Waller, M. B. ; McBride, W. J. ; Lumeng, L. ; Li, T. K. / Induction of dependence on ethanol by free-choice drinking in alcohol-preferring rats. In: Pharmacology Biochemistry and Behavior. 1982 ; Vol. 16, No. 3. pp. 501-507.
@article{17ff518de79b472ab7c395fe7559a00f,
title = "Induction of dependence on ethanol by free-choice drinking in alcohol-preferring rats",
abstract = "Studies were performed to examine whether chronic, voluntary consumption of ethanol by the selectively-bred, alcohol-preferring P-rats produces physical dependence. Body weight reduction, food restriction and flavoring the 10{\%} ethanol solution increased ethanol consumption from 7 to 14 g ethanol/kg body weight/day when water was freely available. Under similar conditions, consumption by selectively-bred, alcohol-nonpreferring NP-rats increased from 1 to 12 g/kg/day. Removal of ethanol after eight weeks induced physical signs of withdrawal in both lines of animals. In two subsequent studies, P-rats were given food, water and unflavored 10{\%} ethanol ad lib for 15 and 20 weeks; ethanol consumption was 7.2 and 5.6 g/kg/day, respectively. Upon removal of ethanol, manifestations of withdrawal, scored blind in one experiment, developed in 85{\%} of the animals and persisted for 72 hours. Importantly, none in the control groups of P and NP rats given water only exhibited these signs. The ethanol withdrawn groups were hyperactive in both the open-field and the head-poke apparatus. These results indicate that sufficient ethanol was voluntarily consumed by the selectively-bred alcohol-preferring P-rats under free-feeding conditions to produce physical dependence.",
keywords = "Alcohol-preferring rats, Ethanol, Oral ethanol consumption, Physical dependence, Withdrawal syndrome",
author = "Waller, {M. B.} and McBride, {W. J.} and L. Lumeng and Li, {T. K.}",
year = "1982",
doi = "10.1016/0091-3057(82)90459-2",
language = "English",
volume = "16",
pages = "501--507",
journal = "Pharmacology, Biochemistry and Behavior",
issn = "0091-3057",
publisher = "Elsevier Inc.",
number = "3",

}

TY - JOUR

T1 - Induction of dependence on ethanol by free-choice drinking in alcohol-preferring rats

AU - Waller, M. B.

AU - McBride, W. J.

AU - Lumeng, L.

AU - Li, T. K.

PY - 1982

Y1 - 1982

N2 - Studies were performed to examine whether chronic, voluntary consumption of ethanol by the selectively-bred, alcohol-preferring P-rats produces physical dependence. Body weight reduction, food restriction and flavoring the 10% ethanol solution increased ethanol consumption from 7 to 14 g ethanol/kg body weight/day when water was freely available. Under similar conditions, consumption by selectively-bred, alcohol-nonpreferring NP-rats increased from 1 to 12 g/kg/day. Removal of ethanol after eight weeks induced physical signs of withdrawal in both lines of animals. In two subsequent studies, P-rats were given food, water and unflavored 10% ethanol ad lib for 15 and 20 weeks; ethanol consumption was 7.2 and 5.6 g/kg/day, respectively. Upon removal of ethanol, manifestations of withdrawal, scored blind in one experiment, developed in 85% of the animals and persisted for 72 hours. Importantly, none in the control groups of P and NP rats given water only exhibited these signs. The ethanol withdrawn groups were hyperactive in both the open-field and the head-poke apparatus. These results indicate that sufficient ethanol was voluntarily consumed by the selectively-bred alcohol-preferring P-rats under free-feeding conditions to produce physical dependence.

AB - Studies were performed to examine whether chronic, voluntary consumption of ethanol by the selectively-bred, alcohol-preferring P-rats produces physical dependence. Body weight reduction, food restriction and flavoring the 10% ethanol solution increased ethanol consumption from 7 to 14 g ethanol/kg body weight/day when water was freely available. Under similar conditions, consumption by selectively-bred, alcohol-nonpreferring NP-rats increased from 1 to 12 g/kg/day. Removal of ethanol after eight weeks induced physical signs of withdrawal in both lines of animals. In two subsequent studies, P-rats were given food, water and unflavored 10% ethanol ad lib for 15 and 20 weeks; ethanol consumption was 7.2 and 5.6 g/kg/day, respectively. Upon removal of ethanol, manifestations of withdrawal, scored blind in one experiment, developed in 85% of the animals and persisted for 72 hours. Importantly, none in the control groups of P and NP rats given water only exhibited these signs. The ethanol withdrawn groups were hyperactive in both the open-field and the head-poke apparatus. These results indicate that sufficient ethanol was voluntarily consumed by the selectively-bred alcohol-preferring P-rats under free-feeding conditions to produce physical dependence.

KW - Alcohol-preferring rats

KW - Ethanol

KW - Oral ethanol consumption

KW - Physical dependence

KW - Withdrawal syndrome

UR - http://www.scopus.com/inward/record.url?scp=0020073707&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020073707&partnerID=8YFLogxK

U2 - 10.1016/0091-3057(82)90459-2

DO - 10.1016/0091-3057(82)90459-2

M3 - Article

VL - 16

SP - 501

EP - 507

JO - Pharmacology, Biochemistry and Behavior

JF - Pharmacology, Biochemistry and Behavior

SN - 0091-3057

IS - 3

ER -