Induction of indoleamine 2, 3-dioxygenase in vivo by IFN-con1

Thayne L. Sweeten, Christopher J. McDougle, Paul Kwo, Mary Ferris, Milton W. Taylor

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Indoleamine 2,3-dioxygenase (IDO) activity as determined by increases in serum kynurenine was measured in a group of hepatitis C patients treated with consensus interferon (IFN-con1). Kynurenine levels increased significantly within 2 days of initiation of treatment but returned to normal values by week 4 after treatment. Although IDO is normally induced by IFN-γ, no such IFN was detected by ELISA or biologic assays. Thus, consensus IFN induces low levels of IDO in vivo without an IFN-γ intermediate.

Original languageEnglish (US)
Pages (from-to)631-633
Number of pages3
JournalJournal of Interferon and Cytokine Research
Volume21
Issue number8
DOIs
StatePublished - Aug 2001

ASJC Scopus subject areas

  • Immunology
  • Cell Biology
  • Virology

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    Sweeten, T. L., McDougle, C. J., Kwo, P., Ferris, M., & Taylor, M. W. (2001). Induction of indoleamine 2, 3-dioxygenase in vivo by IFN-con1. Journal of Interferon and Cytokine Research, 21(8), 631-633. https://doi.org/10.1089/10799900152547894