Induction of meandering functional reentrant wave front in isolated human atrial tissues

Takanori Ikeda, Lawrence Czer, Alfredo Trento, Chun Hwang, James J C Ong, Dustan Hough, Michael C. Fishbein, William J. Mandel, Hrayr S. Karagueuzian, Peng-Sheng Chen

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Background: The purpose of this study was to test the hypothesis that a single meandering functional reentrant wave front can result in rapid and irregular electrogram activity in human atrial tissues. Methods and Results: The study used the explanted hearts of five human cardiac transplant recipients. Three right and two left atrial tissue samples, 3.4±0.3 mm thick, were excised and trimmed to 3.5x3.0 cm. The isolated atrium was placed endocardial surface down in a chamber with a 477 bipolar recording electrode array built into the bottom of the tissue bath. The interelectrode distance was 1.6 min. The tissue was constantly superfused with 36.5°C oxygenated Tyrode's solution at a rate of 10 mL/min. After eight baseline stimuli (S1) delivered at 400- or 600-ms cycle length from the edge of the tissue, a single premature stimulus (S2) was given at the center of the tissue to induce reentry. A total of nine episodes of reentry were induced with S1- S2 coupling intervals of 232±29 ms (range, 190 to 290 ms) and an S2 strength of 10±3 mA (range, 5 to 15 mA). In all samples, a single meandering reentrant wave front was induced, causing irregular and rapid bipolar electrogram activity. These wave fronts had a mean cycle length of 229±45 ms (160 to 290 ms) and persisted for 1.1±0.3 seconds (0.6 seconds to 2.5 seconds), or 5.2±1.4 (3 to 9) cycles, before spontaneous termination. Conclusions: A single meandering functional reentrant wave front can be induced in human atrial tissues and produce rapid and irregular electrical activity.

Original languageEnglish (US)
Pages (from-to)3013-3020
Number of pages8
JournalCirculation
Volume96
Issue number9
StatePublished - Nov 4 1997
Externally publishedYes

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Baths
Human Activities
Electrodes
Tyrode's solution
Transplant Recipients

Keywords

  • Arrhythmia
  • Atrium
  • Electrophysiology
  • Fibrillation
  • Mapping

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Ikeda, T., Czer, L., Trento, A., Hwang, C., Ong, J. J. C., Hough, D., ... Chen, P-S. (1997). Induction of meandering functional reentrant wave front in isolated human atrial tissues. Circulation, 96(9), 3013-3020.

Induction of meandering functional reentrant wave front in isolated human atrial tissues. / Ikeda, Takanori; Czer, Lawrence; Trento, Alfredo; Hwang, Chun; Ong, James J C; Hough, Dustan; Fishbein, Michael C.; Mandel, William J.; Karagueuzian, Hrayr S.; Chen, Peng-Sheng.

In: Circulation, Vol. 96, No. 9, 04.11.1997, p. 3013-3020.

Research output: Contribution to journalArticle

Ikeda, T, Czer, L, Trento, A, Hwang, C, Ong, JJC, Hough, D, Fishbein, MC, Mandel, WJ, Karagueuzian, HS & Chen, P-S 1997, 'Induction of meandering functional reentrant wave front in isolated human atrial tissues', Circulation, vol. 96, no. 9, pp. 3013-3020.
Ikeda T, Czer L, Trento A, Hwang C, Ong JJC, Hough D et al. Induction of meandering functional reentrant wave front in isolated human atrial tissues. Circulation. 1997 Nov 4;96(9):3013-3020.
Ikeda, Takanori ; Czer, Lawrence ; Trento, Alfredo ; Hwang, Chun ; Ong, James J C ; Hough, Dustan ; Fishbein, Michael C. ; Mandel, William J. ; Karagueuzian, Hrayr S. ; Chen, Peng-Sheng. / Induction of meandering functional reentrant wave front in isolated human atrial tissues. In: Circulation. 1997 ; Vol. 96, No. 9. pp. 3013-3020.
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abstract = "Background: The purpose of this study was to test the hypothesis that a single meandering functional reentrant wave front can result in rapid and irregular electrogram activity in human atrial tissues. Methods and Results: The study used the explanted hearts of five human cardiac transplant recipients. Three right and two left atrial tissue samples, 3.4±0.3 mm thick, were excised and trimmed to 3.5x3.0 cm. The isolated atrium was placed endocardial surface down in a chamber with a 477 bipolar recording electrode array built into the bottom of the tissue bath. The interelectrode distance was 1.6 min. The tissue was constantly superfused with 36.5°C oxygenated Tyrode's solution at a rate of 10 mL/min. After eight baseline stimuli (S1) delivered at 400- or 600-ms cycle length from the edge of the tissue, a single premature stimulus (S2) was given at the center of the tissue to induce reentry. A total of nine episodes of reentry were induced with S1- S2 coupling intervals of 232±29 ms (range, 190 to 290 ms) and an S2 strength of 10±3 mA (range, 5 to 15 mA). In all samples, a single meandering reentrant wave front was induced, causing irregular and rapid bipolar electrogram activity. These wave fronts had a mean cycle length of 229±45 ms (160 to 290 ms) and persisted for 1.1±0.3 seconds (0.6 seconds to 2.5 seconds), or 5.2±1.4 (3 to 9) cycles, before spontaneous termination. Conclusions: A single meandering functional reentrant wave front can be induced in human atrial tissues and produce rapid and irregular electrical activity.",
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AU - Ikeda, Takanori

AU - Czer, Lawrence

AU - Trento, Alfredo

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AU - Ong, James J C

AU - Hough, Dustan

AU - Fishbein, Michael C.

AU - Mandel, William J.

AU - Karagueuzian, Hrayr S.

AU - Chen, Peng-Sheng

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N2 - Background: The purpose of this study was to test the hypothesis that a single meandering functional reentrant wave front can result in rapid and irregular electrogram activity in human atrial tissues. Methods and Results: The study used the explanted hearts of five human cardiac transplant recipients. Three right and two left atrial tissue samples, 3.4±0.3 mm thick, were excised and trimmed to 3.5x3.0 cm. The isolated atrium was placed endocardial surface down in a chamber with a 477 bipolar recording electrode array built into the bottom of the tissue bath. The interelectrode distance was 1.6 min. The tissue was constantly superfused with 36.5°C oxygenated Tyrode's solution at a rate of 10 mL/min. After eight baseline stimuli (S1) delivered at 400- or 600-ms cycle length from the edge of the tissue, a single premature stimulus (S2) was given at the center of the tissue to induce reentry. A total of nine episodes of reentry were induced with S1- S2 coupling intervals of 232±29 ms (range, 190 to 290 ms) and an S2 strength of 10±3 mA (range, 5 to 15 mA). In all samples, a single meandering reentrant wave front was induced, causing irregular and rapid bipolar electrogram activity. These wave fronts had a mean cycle length of 229±45 ms (160 to 290 ms) and persisted for 1.1±0.3 seconds (0.6 seconds to 2.5 seconds), or 5.2±1.4 (3 to 9) cycles, before spontaneous termination. Conclusions: A single meandering functional reentrant wave front can be induced in human atrial tissues and produce rapid and irregular electrical activity.

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KW - Electrophysiology

KW - Fibrillation

KW - Mapping

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