Induction of meandering functional reentrant wave front in isolated human atrial tissues

Takanori Ikeda, Lawrence Czer, Alfredo Trento, Chun Hwang, James J.C. Ong, Dustan Hough, Michael C. Fishbein, William J. Mandel, Hrayr S. Karagueuzian, Peng Sheng Chen

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Background: The purpose of this study was to test the hypothesis that a single meandering functional reentrant wave front can result in rapid and irregular electrogram activity in human atrial tissues. Methods and Results: The study used the explanted hearts of five human cardiac transplant recipients. Three right and two left atrial tissue samples, 3.4±0.3 mm thick, were excised and trimmed to 3.5x3.0 cm. The isolated atrium was placed endocardial surface down in a chamber with a 477 bipolar recording electrode array built into the bottom of the tissue bath. The interelectrode distance was 1.6 min. The tissue was constantly superfused with 36.5°C oxygenated Tyrode's solution at a rate of 10 mL/min. After eight baseline stimuli (S1) delivered at 400- or 600-ms cycle length from the edge of the tissue, a single premature stimulus (S2) was given at the center of the tissue to induce reentry. A total of nine episodes of reentry were induced with S1- S2 coupling intervals of 232±29 ms (range, 190 to 290 ms) and an S2 strength of 10±3 mA (range, 5 to 15 mA). In all samples, a single meandering reentrant wave front was induced, causing irregular and rapid bipolar electrogram activity. These wave fronts had a mean cycle length of 229±45 ms (160 to 290 ms) and persisted for 1.1±0.3 seconds (0.6 seconds to 2.5 seconds), or 5.2±1.4 (3 to 9) cycles, before spontaneous termination. Conclusions: A single meandering functional reentrant wave front can be induced in human atrial tissues and produce rapid and irregular electrical activity.

Original languageEnglish (US)
Pages (from-to)3013-3020
Number of pages8
JournalCirculation
Volume96
Issue number9
DOIs
StatePublished - Nov 4 1997

Fingerprint

Baths
Human Activities
Electrodes
Tyrode's solution
Transplant Recipients

Keywords

  • Arrhythmia
  • Atrium
  • Electrophysiology
  • Fibrillation
  • Mapping

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Induction of meandering functional reentrant wave front in isolated human atrial tissues. / Ikeda, Takanori; Czer, Lawrence; Trento, Alfredo; Hwang, Chun; Ong, James J.C.; Hough, Dustan; Fishbein, Michael C.; Mandel, William J.; Karagueuzian, Hrayr S.; Chen, Peng Sheng.

In: Circulation, Vol. 96, No. 9, 04.11.1997, p. 3013-3020.

Research output: Contribution to journalArticle

Ikeda, T, Czer, L, Trento, A, Hwang, C, Ong, JJC, Hough, D, Fishbein, MC, Mandel, WJ, Karagueuzian, HS & Chen, PS 1997, 'Induction of meandering functional reentrant wave front in isolated human atrial tissues', Circulation, vol. 96, no. 9, pp. 3013-3020. https://doi.org/10.1161/01.CIR.96.9.3013
Ikeda, Takanori ; Czer, Lawrence ; Trento, Alfredo ; Hwang, Chun ; Ong, James J.C. ; Hough, Dustan ; Fishbein, Michael C. ; Mandel, William J. ; Karagueuzian, Hrayr S. ; Chen, Peng Sheng. / Induction of meandering functional reentrant wave front in isolated human atrial tissues. In: Circulation. 1997 ; Vol. 96, No. 9. pp. 3013-3020.
@article{2390f6da1d2e4b0ebeceae9cc9279375,
title = "Induction of meandering functional reentrant wave front in isolated human atrial tissues",
abstract = "Background: The purpose of this study was to test the hypothesis that a single meandering functional reentrant wave front can result in rapid and irregular electrogram activity in human atrial tissues. Methods and Results: The study used the explanted hearts of five human cardiac transplant recipients. Three right and two left atrial tissue samples, 3.4±0.3 mm thick, were excised and trimmed to 3.5x3.0 cm. The isolated atrium was placed endocardial surface down in a chamber with a 477 bipolar recording electrode array built into the bottom of the tissue bath. The interelectrode distance was 1.6 min. The tissue was constantly superfused with 36.5°C oxygenated Tyrode's solution at a rate of 10 mL/min. After eight baseline stimuli (S1) delivered at 400- or 600-ms cycle length from the edge of the tissue, a single premature stimulus (S2) was given at the center of the tissue to induce reentry. A total of nine episodes of reentry were induced with S1- S2 coupling intervals of 232±29 ms (range, 190 to 290 ms) and an S2 strength of 10±3 mA (range, 5 to 15 mA). In all samples, a single meandering reentrant wave front was induced, causing irregular and rapid bipolar electrogram activity. These wave fronts had a mean cycle length of 229±45 ms (160 to 290 ms) and persisted for 1.1±0.3 seconds (0.6 seconds to 2.5 seconds), or 5.2±1.4 (3 to 9) cycles, before spontaneous termination. Conclusions: A single meandering functional reentrant wave front can be induced in human atrial tissues and produce rapid and irregular electrical activity.",
keywords = "Arrhythmia, Atrium, Electrophysiology, Fibrillation, Mapping",
author = "Takanori Ikeda and Lawrence Czer and Alfredo Trento and Chun Hwang and Ong, {James J.C.} and Dustan Hough and Fishbein, {Michael C.} and Mandel, {William J.} and Karagueuzian, {Hrayr S.} and Chen, {Peng Sheng}",
year = "1997",
month = "11",
day = "4",
doi = "10.1161/01.CIR.96.9.3013",
language = "English (US)",
volume = "96",
pages = "3013--3020",
journal = "Circulation",
issn = "0009-7322",
publisher = "Lippincott Williams and Wilkins",
number = "9",

}

TY - JOUR

T1 - Induction of meandering functional reentrant wave front in isolated human atrial tissues

AU - Ikeda, Takanori

AU - Czer, Lawrence

AU - Trento, Alfredo

AU - Hwang, Chun

AU - Ong, James J.C.

AU - Hough, Dustan

AU - Fishbein, Michael C.

AU - Mandel, William J.

AU - Karagueuzian, Hrayr S.

AU - Chen, Peng Sheng

PY - 1997/11/4

Y1 - 1997/11/4

N2 - Background: The purpose of this study was to test the hypothesis that a single meandering functional reentrant wave front can result in rapid and irregular electrogram activity in human atrial tissues. Methods and Results: The study used the explanted hearts of five human cardiac transplant recipients. Three right and two left atrial tissue samples, 3.4±0.3 mm thick, were excised and trimmed to 3.5x3.0 cm. The isolated atrium was placed endocardial surface down in a chamber with a 477 bipolar recording electrode array built into the bottom of the tissue bath. The interelectrode distance was 1.6 min. The tissue was constantly superfused with 36.5°C oxygenated Tyrode's solution at a rate of 10 mL/min. After eight baseline stimuli (S1) delivered at 400- or 600-ms cycle length from the edge of the tissue, a single premature stimulus (S2) was given at the center of the tissue to induce reentry. A total of nine episodes of reentry were induced with S1- S2 coupling intervals of 232±29 ms (range, 190 to 290 ms) and an S2 strength of 10±3 mA (range, 5 to 15 mA). In all samples, a single meandering reentrant wave front was induced, causing irregular and rapid bipolar electrogram activity. These wave fronts had a mean cycle length of 229±45 ms (160 to 290 ms) and persisted for 1.1±0.3 seconds (0.6 seconds to 2.5 seconds), or 5.2±1.4 (3 to 9) cycles, before spontaneous termination. Conclusions: A single meandering functional reentrant wave front can be induced in human atrial tissues and produce rapid and irregular electrical activity.

AB - Background: The purpose of this study was to test the hypothesis that a single meandering functional reentrant wave front can result in rapid and irregular electrogram activity in human atrial tissues. Methods and Results: The study used the explanted hearts of five human cardiac transplant recipients. Three right and two left atrial tissue samples, 3.4±0.3 mm thick, were excised and trimmed to 3.5x3.0 cm. The isolated atrium was placed endocardial surface down in a chamber with a 477 bipolar recording electrode array built into the bottom of the tissue bath. The interelectrode distance was 1.6 min. The tissue was constantly superfused with 36.5°C oxygenated Tyrode's solution at a rate of 10 mL/min. After eight baseline stimuli (S1) delivered at 400- or 600-ms cycle length from the edge of the tissue, a single premature stimulus (S2) was given at the center of the tissue to induce reentry. A total of nine episodes of reentry were induced with S1- S2 coupling intervals of 232±29 ms (range, 190 to 290 ms) and an S2 strength of 10±3 mA (range, 5 to 15 mA). In all samples, a single meandering reentrant wave front was induced, causing irregular and rapid bipolar electrogram activity. These wave fronts had a mean cycle length of 229±45 ms (160 to 290 ms) and persisted for 1.1±0.3 seconds (0.6 seconds to 2.5 seconds), or 5.2±1.4 (3 to 9) cycles, before spontaneous termination. Conclusions: A single meandering functional reentrant wave front can be induced in human atrial tissues and produce rapid and irregular electrical activity.

KW - Arrhythmia

KW - Atrium

KW - Electrophysiology

KW - Fibrillation

KW - Mapping

UR - http://www.scopus.com/inward/record.url?scp=0030720305&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030720305&partnerID=8YFLogxK

U2 - 10.1161/01.CIR.96.9.3013

DO - 10.1161/01.CIR.96.9.3013

M3 - Article

C2 - 9386170

AN - SCOPUS:0030720305

VL - 96

SP - 3013

EP - 3020

JO - Circulation

JF - Circulation

SN - 0009-7322

IS - 9

ER -