Induction of pulmonary immunity in cattle by the oral administration of antigen encapsulated in alginate microspheres

T. L. Bowersock, Harm HogenEsch, B. Wang, S. Torregrosa, D. L. Borie, H. Park, K. Park

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Mucosal immunity of the respiratory tract can be induced by the oral administration of antigens. Oral vaccines are easy to administer to a large number of animals. However, the antigens must be protected from the acid and enzymes of the stomach. Encapsulation in polymeric microspheres is one method to protect and enhance delivery of antigens to the inductive immune sites in the small intestine. In this study, ovalbumin was used as a test antigen encapsulated in alginate microspheres. Oral administration of ovalbumin in alginate microspheres resulted in the appearance of IgA-secreting cells in the lungs of calves. The oral administration of vaccines to cattle could be a cost effective way to prevent economically important diseases, such as respiratory infections, in cattle.

Original languageEnglish (US)
Pages (from-to)53-57
Number of pages5
JournalS.T.P. Pharma Sciences
Volume8
Issue number1
StatePublished - Jan 1998
Externally publishedYes

Fingerprint

Microspheres
Oral Administration
Immunity
Antigens
Lung
Ovalbumin
Vaccines
Mucosal Immunity
Respiratory Tract Infections
Respiratory System
Immunoglobulin A
Small Intestine
Stomach
Costs and Cost Analysis
Acids
alginic acid
Enzymes

Keywords

  • Alginate
  • Cattle
  • IgA
  • Microspheres
  • Mucosalimmunity
  • Respiratory
  • Vaccine

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Bowersock, T. L., HogenEsch, H., Wang, B., Torregrosa, S., Borie, D. L., Park, H., & Park, K. (1998). Induction of pulmonary immunity in cattle by the oral administration of antigen encapsulated in alginate microspheres. S.T.P. Pharma Sciences, 8(1), 53-57.

Induction of pulmonary immunity in cattle by the oral administration of antigen encapsulated in alginate microspheres. / Bowersock, T. L.; HogenEsch, Harm; Wang, B.; Torregrosa, S.; Borie, D. L.; Park, H.; Park, K.

In: S.T.P. Pharma Sciences, Vol. 8, No. 1, 01.1998, p. 53-57.

Research output: Contribution to journalArticle

Bowersock, TL, HogenEsch, H, Wang, B, Torregrosa, S, Borie, DL, Park, H & Park, K 1998, 'Induction of pulmonary immunity in cattle by the oral administration of antigen encapsulated in alginate microspheres', S.T.P. Pharma Sciences, vol. 8, no. 1, pp. 53-57.
Bowersock, T. L. ; HogenEsch, Harm ; Wang, B. ; Torregrosa, S. ; Borie, D. L. ; Park, H. ; Park, K. / Induction of pulmonary immunity in cattle by the oral administration of antigen encapsulated in alginate microspheres. In: S.T.P. Pharma Sciences. 1998 ; Vol. 8, No. 1. pp. 53-57.
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