Induction of testosterone metabolism by esomeprazole in a CYP2C19*2 heterozygote

Beth Rosenshein, David A. Flockhart, Herbert Ho

Research output: Contribution to journalArticle

6 Scopus citations


The authors describe a 42-year-old woman with previously normal sexual function who gradually developed loss of libido during treatment with esomeprazole. While taking esomeprazole, the patient's loss of libido improved with oral testosterone supplementation and deteriorated after testosterone withdrawal. There was steady improvement in both sexual function and serum free testosterone concentration after discontinuation of esomeprazole. Due to the temporal relationship between esomeprazole intake and sexual dysfunction, the authors postulate that esomeprazole causes induction of testosterone metabolism. The authors believe this to be the first case of female sexual dysfunction associated with esomeprazole described in the literature. They discuss a number of possible mechanisms for this effect.

Original languageEnglish (US)
Pages (from-to)289-293
Number of pages5
JournalAmerican Journal of the Medical Sciences
Issue number5
StatePublished - May 2004


  • Esomeprazole
  • Libido
  • Testosterone

ASJC Scopus subject areas

  • Medicine(all)

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