Inert gas transport in the microcirculation

Risk of isobaric supersaturation

Robert Tepper, E. N. Lightfoot, A. Baz, E. H. Lanphier

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

This paper is concerned with the theoretical background and implications of isobaric supersaturation and bubble formation in the microcirculation following an abrupt shift from one inspired inert gas to another. The use of more than one inert gas, simultaneously or sequentially, has become common in diving and presents risks as well as potential benefits. A review of microcirculatory models, theoretical approaches to decompression, and order of magnitude calculations indicates that present empiricisms are inadequate for predicting such supersaturation phenomena. This is true whether based on the familiar assumption of perfusion-limited behavior or its diffusion-limited counterpart. The 'chromatographic' model used here, which considers both perfusion and axial diffusion in tissue cylinders, shows that these combined effects can produce unexpectedly high local supersaturation. The implications include new possibilities for the experimental evaluation of gas transport models as well as practical risks of inert gas shifts in diving and certain diagnostic procedures.

Original languageEnglish (US)
Pages (from-to)1157-1163
Number of pages7
JournalJournal of Applied Physiology Respiratory Environmental and Exercise Physiology
Volume46
Issue number6
StatePublished - 1979
Externally publishedYes

Fingerprint

Noble Gases
Microcirculation
Diving
Perfusion
Decompression
Theoretical Models
Gases

ASJC Scopus subject areas

  • Endocrinology
  • Physiology

Cite this

Inert gas transport in the microcirculation : Risk of isobaric supersaturation. / Tepper, Robert; Lightfoot, E. N.; Baz, A.; Lanphier, E. H.

In: Journal of Applied Physiology Respiratory Environmental and Exercise Physiology, Vol. 46, No. 6, 1979, p. 1157-1163.

Research output: Contribution to journalArticle

@article{0098331a594e40e691862088e2cb810e,
title = "Inert gas transport in the microcirculation: Risk of isobaric supersaturation",
abstract = "This paper is concerned with the theoretical background and implications of isobaric supersaturation and bubble formation in the microcirculation following an abrupt shift from one inspired inert gas to another. The use of more than one inert gas, simultaneously or sequentially, has become common in diving and presents risks as well as potential benefits. A review of microcirculatory models, theoretical approaches to decompression, and order of magnitude calculations indicates that present empiricisms are inadequate for predicting such supersaturation phenomena. This is true whether based on the familiar assumption of perfusion-limited behavior or its diffusion-limited counterpart. The 'chromatographic' model used here, which considers both perfusion and axial diffusion in tissue cylinders, shows that these combined effects can produce unexpectedly high local supersaturation. The implications include new possibilities for the experimental evaluation of gas transport models as well as practical risks of inert gas shifts in diving and certain diagnostic procedures.",
author = "Robert Tepper and Lightfoot, {E. N.} and A. Baz and Lanphier, {E. H.}",
year = "1979",
language = "English (US)",
volume = "46",
pages = "1157--1163",
journal = "Journal of Applied Physiology",
issn = "8750-7587",
publisher = "American Physiological Society",
number = "6",

}

TY - JOUR

T1 - Inert gas transport in the microcirculation

T2 - Risk of isobaric supersaturation

AU - Tepper, Robert

AU - Lightfoot, E. N.

AU - Baz, A.

AU - Lanphier, E. H.

PY - 1979

Y1 - 1979

N2 - This paper is concerned with the theoretical background and implications of isobaric supersaturation and bubble formation in the microcirculation following an abrupt shift from one inspired inert gas to another. The use of more than one inert gas, simultaneously or sequentially, has become common in diving and presents risks as well as potential benefits. A review of microcirculatory models, theoretical approaches to decompression, and order of magnitude calculations indicates that present empiricisms are inadequate for predicting such supersaturation phenomena. This is true whether based on the familiar assumption of perfusion-limited behavior or its diffusion-limited counterpart. The 'chromatographic' model used here, which considers both perfusion and axial diffusion in tissue cylinders, shows that these combined effects can produce unexpectedly high local supersaturation. The implications include new possibilities for the experimental evaluation of gas transport models as well as practical risks of inert gas shifts in diving and certain diagnostic procedures.

AB - This paper is concerned with the theoretical background and implications of isobaric supersaturation and bubble formation in the microcirculation following an abrupt shift from one inspired inert gas to another. The use of more than one inert gas, simultaneously or sequentially, has become common in diving and presents risks as well as potential benefits. A review of microcirculatory models, theoretical approaches to decompression, and order of magnitude calculations indicates that present empiricisms are inadequate for predicting such supersaturation phenomena. This is true whether based on the familiar assumption of perfusion-limited behavior or its diffusion-limited counterpart. The 'chromatographic' model used here, which considers both perfusion and axial diffusion in tissue cylinders, shows that these combined effects can produce unexpectedly high local supersaturation. The implications include new possibilities for the experimental evaluation of gas transport models as well as practical risks of inert gas shifts in diving and certain diagnostic procedures.

UR - http://www.scopus.com/inward/record.url?scp=0018578092&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018578092&partnerID=8YFLogxK

M3 - Article

VL - 46

SP - 1157

EP - 1163

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 8750-7587

IS - 6

ER -