Infection and transformation of Fν-2rr erythroprogenitor cells with Friend virus

Roy W. Geib, Mark Dizik, Rita Anand, Frank Lilly

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Friend virus was used to infect and transform Fv-2rr erythroprogenitor cells in vivo. The RB (Fv-2rr) cell line was characteristic of Friend virus-induced cell lines in Fv-2ss mice, i.e., it produced infectious Friend virus and synthesized hemoglobin. The RB (Fv-2rr) cell line expressed the envelope protein of the spleen focus-forming virus (gp52) and a novel, related envelope protein (gp48). The results demonstrate that Fv-2rr erythroprogenitor cells can be infected and transformed in vivo.

Original languageEnglish
Pages (from-to)327-333
Number of pages7
JournalVirus Research
Volume8
Issue number4
DOIs
StatePublished - 1987

Fingerprint

Friend murine leukemia virus
Cell Line
Infection
Hemoglobins
Proteins

Keywords

  • Erythroleukemia
  • Friend virus
  • Fv-2
  • Retrovirus

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Virology

Cite this

Infection and transformation of Fν-2rr erythroprogenitor cells with Friend virus. / Geib, Roy W.; Dizik, Mark; Anand, Rita; Lilly, Frank.

In: Virus Research, Vol. 8, No. 4, 1987, p. 327-333.

Research output: Contribution to journalArticle

Geib, Roy W. ; Dizik, Mark ; Anand, Rita ; Lilly, Frank. / Infection and transformation of Fν-2rr erythroprogenitor cells with Friend virus. In: Virus Research. 1987 ; Vol. 8, No. 4. pp. 327-333.
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