Infection and transformation of Fν-2rr erythroprogenitor cells with Friend virus

Roy W. Geib, Mark Dizik, Rita Anand, Frank Lilly

Research output: Contribution to journalArticle

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Abstract

Friend virus was used to infect and transform Fv-2rr erythroprogenitor cells in vivo. The RB (Fv-2rr) cell line was characteristic of Friend virus-induced cell lines in Fv-2ss mice, i.e., it produced infectious Friend virus and synthesized hemoglobin. The RB (Fv-2rr) cell line expressed the envelope protein of the spleen focus-forming virus (gp52) and a novel, related envelope protein (gp48). The results demonstrate that Fv-2rr erythroprogenitor cells can be infected and transformed in vivo.

Original languageEnglish (US)
Pages (from-to)327-333
Number of pages7
JournalVirus Research
Volume8
Issue number4
DOIs
StatePublished - Nov 1987

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Keywords

  • Erythroleukemia
  • Friend virus
  • Fv-2
  • Retrovirus

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Virology

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