Infectious complications of cyclophosphamide treatment for vasculitis

J. D. Bradley, K. D. Brandt, Barry Katz

Research output: Contribution to journalArticle

115 Citations (Scopus)

Abstract

Fifteen patients with Wegener's granulomatosis, polyarteritis nodosa, or isolated angiitis of the central nervous system were treated iwth cyclophosphamide according to a widely used regimen. Seventeen clinical episodes of infection were observed over 201 patient-months of cyclophosphamide therapy, and 2 patients died of pneumonia. Notably, neither the incidence of leukopenia nor the dosage or duration of cyclophosphamide or corticosteroid therapy correlated well with infection, which occurred most frequently in men over 60 years of age. Patients with Wegener's granulomatosis appeared to be at greater risk of infection than those with the other forms of vasculitis. These results suggest that this treatment regimen may not be as safe as was previously thought.

Original languageEnglish
Pages (from-to)45-53
Number of pages9
JournalArthritis and Rheumatism
Volume32
Issue number1
StatePublished - 1989

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Vasculitis
Cyclophosphamide
Granulomatosis with Polyangiitis
Infection
Central Nervous System Vasculitis
Polyarteritis Nodosa
Leukopenia
Therapeutics
Pneumonia
Adrenal Cortex Hormones
Incidence

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Cite this

Infectious complications of cyclophosphamide treatment for vasculitis. / Bradley, J. D.; Brandt, K. D.; Katz, Barry.

In: Arthritis and Rheumatism, Vol. 32, No. 1, 1989, p. 45-53.

Research output: Contribution to journalArticle

Bradley, J. D. ; Brandt, K. D. ; Katz, Barry. / Infectious complications of cyclophosphamide treatment for vasculitis. In: Arthritis and Rheumatism. 1989 ; Vol. 32, No. 1. pp. 45-53.
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