Inflammatory mediators and growth factors in obstructive renal injury

Rosalia Misseri, Richard C. Rink, Daniel R. Meldrum, Kirstan K. Meldrum

Research output: Contribution to journalReview articlepeer-review

64 Scopus citations

Abstract

Obstruction of the upper urinary tract poses a significant clinical challenge to the urologist, and the cascade of renal cellular and molecular events triggered by upper urinary tract obstruction result in a progressive, and eventually permanent, loss in renal function. These pathological changes include the development of renal fibrosis, tubular atrophy, interstitial inflammation, and apoptotic renal cell death. A myriad of cytokines and growth factors have been identified as major contributors to obstruction-induced renal fibrosis and apoptotic cell death, including transforming growth factor-β1, angiotensin II, nuclear factor-κB, and tumor necrosis factor-α. This review examines the role of these mediators in obstruction-induced renal injury.

Original languageEnglish (US)
Pages (from-to)149-159
Number of pages11
JournalJournal of Surgical Research
Volume119
Issue number2
DOIs
StatePublished - Jun 15 2004

Keywords

  • apoptosis
  • kidney
  • tubulointerstitial fibrosis

ASJC Scopus subject areas

  • Surgery

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