Inflammatory myofibroblastic tumor of larynx

a benign lesion with variable morphological spectrum

Muhammad Idrees, Youming Huan, Peak Woo, Beverly Y. Wang

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Inflammatory myofibroblastic tumor is a recently characterized lesion, composed of exuberant myofibroblastic proliferation and an inflammatory component. Its etiology remains controversial, as to whether this represents a benign tumor with limited potential to recur or progress. Exaggerated response to trauma or infection has also been implicated. Only a few cases of laryngeal inflammatory myofibroblastic tumor have been described in English after it has been assigned the new name. The prototype lesion, inflammatory pseudotumor, has been best described in association with the lung but has also been reported involving various organs. We report 2 additional cases with a considerable variation in the presentation and histology of the lesion, thus expanding the morphological spectrum of the entity. Both lesions appeared aggressive in clinical presentation. One case had relatively more pleomorphic appearance and increased mitotic rate. Both lesions were surgically resected, and complete voice preservation was achieved. No postoperative complications or recurrence were noticed. This uncommon neoplasm may appear clinically as a large infiltrating mass and may be mistaken as a malignant growth. Conservative resection of the tumor may provide a cure with adequate voice preservation.

Original languageEnglish (US)
Pages (from-to)433-439
Number of pages7
JournalAnnals of Diagnostic Pathology
Volume11
Issue number6
DOIs
StatePublished - Dec 2007
Externally publishedYes

Fingerprint

Larynx
Neoplasms
Plasma Cell Granuloma
Names
Histology
Recurrence
Lung
Wounds and Injuries
Growth
Infection

Keywords

  • ALK1
  • Immunohistochemical studies
  • Inflammatory myofibroblastic tumor
  • Inflammatory pseudotumor
  • Plasma cell granuloma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Inflammatory myofibroblastic tumor of larynx : a benign lesion with variable morphological spectrum. / Idrees, Muhammad; Huan, Youming; Woo, Peak; Wang, Beverly Y.

In: Annals of Diagnostic Pathology, Vol. 11, No. 6, 12.2007, p. 433-439.

Research output: Contribution to journalArticle

@article{f44a0e843b2c411582ad9984ab9dfed6,
title = "Inflammatory myofibroblastic tumor of larynx: a benign lesion with variable morphological spectrum",
abstract = "Inflammatory myofibroblastic tumor is a recently characterized lesion, composed of exuberant myofibroblastic proliferation and an inflammatory component. Its etiology remains controversial, as to whether this represents a benign tumor with limited potential to recur or progress. Exaggerated response to trauma or infection has also been implicated. Only a few cases of laryngeal inflammatory myofibroblastic tumor have been described in English after it has been assigned the new name. The prototype lesion, inflammatory pseudotumor, has been best described in association with the lung but has also been reported involving various organs. We report 2 additional cases with a considerable variation in the presentation and histology of the lesion, thus expanding the morphological spectrum of the entity. Both lesions appeared aggressive in clinical presentation. One case had relatively more pleomorphic appearance and increased mitotic rate. Both lesions were surgically resected, and complete voice preservation was achieved. No postoperative complications or recurrence were noticed. This uncommon neoplasm may appear clinically as a large infiltrating mass and may be mistaken as a malignant growth. Conservative resection of the tumor may provide a cure with adequate voice preservation.",
keywords = "ALK1, Immunohistochemical studies, Inflammatory myofibroblastic tumor, Inflammatory pseudotumor, Plasma cell granuloma",
author = "Muhammad Idrees and Youming Huan and Peak Woo and Wang, {Beverly Y.}",
year = "2007",
month = "12",
doi = "10.1016/j.anndiagpath.2007.04.004",
language = "English (US)",
volume = "11",
pages = "433--439",
journal = "Annals of Diagnostic Pathology",
issn = "1092-9134",
publisher = "W.B. Saunders Ltd",
number = "6",

}

TY - JOUR

T1 - Inflammatory myofibroblastic tumor of larynx

T2 - a benign lesion with variable morphological spectrum

AU - Idrees, Muhammad

AU - Huan, Youming

AU - Woo, Peak

AU - Wang, Beverly Y.

PY - 2007/12

Y1 - 2007/12

N2 - Inflammatory myofibroblastic tumor is a recently characterized lesion, composed of exuberant myofibroblastic proliferation and an inflammatory component. Its etiology remains controversial, as to whether this represents a benign tumor with limited potential to recur or progress. Exaggerated response to trauma or infection has also been implicated. Only a few cases of laryngeal inflammatory myofibroblastic tumor have been described in English after it has been assigned the new name. The prototype lesion, inflammatory pseudotumor, has been best described in association with the lung but has also been reported involving various organs. We report 2 additional cases with a considerable variation in the presentation and histology of the lesion, thus expanding the morphological spectrum of the entity. Both lesions appeared aggressive in clinical presentation. One case had relatively more pleomorphic appearance and increased mitotic rate. Both lesions were surgically resected, and complete voice preservation was achieved. No postoperative complications or recurrence were noticed. This uncommon neoplasm may appear clinically as a large infiltrating mass and may be mistaken as a malignant growth. Conservative resection of the tumor may provide a cure with adequate voice preservation.

AB - Inflammatory myofibroblastic tumor is a recently characterized lesion, composed of exuberant myofibroblastic proliferation and an inflammatory component. Its etiology remains controversial, as to whether this represents a benign tumor with limited potential to recur or progress. Exaggerated response to trauma or infection has also been implicated. Only a few cases of laryngeal inflammatory myofibroblastic tumor have been described in English after it has been assigned the new name. The prototype lesion, inflammatory pseudotumor, has been best described in association with the lung but has also been reported involving various organs. We report 2 additional cases with a considerable variation in the presentation and histology of the lesion, thus expanding the morphological spectrum of the entity. Both lesions appeared aggressive in clinical presentation. One case had relatively more pleomorphic appearance and increased mitotic rate. Both lesions were surgically resected, and complete voice preservation was achieved. No postoperative complications or recurrence were noticed. This uncommon neoplasm may appear clinically as a large infiltrating mass and may be mistaken as a malignant growth. Conservative resection of the tumor may provide a cure with adequate voice preservation.

KW - ALK1

KW - Immunohistochemical studies

KW - Inflammatory myofibroblastic tumor

KW - Inflammatory pseudotumor

KW - Plasma cell granuloma

UR - http://www.scopus.com/inward/record.url?scp=36049018965&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=36049018965&partnerID=8YFLogxK

U2 - 10.1016/j.anndiagpath.2007.04.004

DO - 10.1016/j.anndiagpath.2007.04.004

M3 - Article

VL - 11

SP - 433

EP - 439

JO - Annals of Diagnostic Pathology

JF - Annals of Diagnostic Pathology

SN - 1092-9134

IS - 6

ER -