Inflammatory myofibroblastic tumors

Stephen J. Kovach, Anne C. Fischer, Philip J. Katzman, Rabih M. Salloum, Stephen E. Ettinghausen, Ralph Madeb, Leonidas Koniaris

Research output: Contribution to journalArticle

177 Citations (Scopus)

Abstract

Introduction: Inflammatory myofibroblastic tumors (IMT) while uncommon may arise within numerous organs. Historically, the literature regarding IMT has been confined to small one organ case series, with few reviews encompassing multiple anatomic sites, and little data regarding adjuvant treatment. Methods: A review of patients with IMT treated at two large academic medical centers over a 15-year period was undertaken. Patient demographics, pathologic diagnoses, and pertinent clinical data were obtained. Results: Forty-four cases of pathologically confirmed IMT were identified. Tumor locations included multiple anatomic sites. Therapies included complete resection, incomplete resection, observation, or chemotherapy, and/or radiation. Five patients underwent adjuvant chemotherapy and/or radiation therapy following surgery (14%) for local aggressiveness of the tumor, invasion, positive margins, or location of tumor that was not amenable to surgical resection. A second, concomitant, histologically distinct, neoplasm was identified in five cases. Of the patients who underwent treatment three local recurrences were noted (8%) and occurred in patients with partial resection without adjuvant chemo- or radiotherapy. Conclusions: Inflammatory myofibroblastic tumors may be a locally aggressive and destructive neoplasm. Tumor recurrence is unusual following complete surgical resection or organ-preserving combined modality therapy.

Original languageEnglish (US)
Pages (from-to)385-391
Number of pages7
JournalJournal of Surgical Oncology
Volume94
Issue number5
DOIs
StatePublished - Oct 1 2006
Externally publishedYes

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Neoplasms
Adjuvant Chemotherapy
Recurrence
Combined Modality Therapy
Adjuvant Radiotherapy
Radiotherapy
Therapeutics
Observation
Demography
Radiation
Drug Therapy

Keywords

  • Fibromyxoid
  • Inflammatory myofibroblastic tumor
  • Inflammatory pseudotumor
  • Pseudosarcomatous myofibroblastic
  • Spindle cell granuloma

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Kovach, S. J., Fischer, A. C., Katzman, P. J., Salloum, R. M., Ettinghausen, S. E., Madeb, R., & Koniaris, L. (2006). Inflammatory myofibroblastic tumors. Journal of Surgical Oncology, 94(5), 385-391. https://doi.org/10.1002/jso.20516

Inflammatory myofibroblastic tumors. / Kovach, Stephen J.; Fischer, Anne C.; Katzman, Philip J.; Salloum, Rabih M.; Ettinghausen, Stephen E.; Madeb, Ralph; Koniaris, Leonidas.

In: Journal of Surgical Oncology, Vol. 94, No. 5, 01.10.2006, p. 385-391.

Research output: Contribution to journalArticle

Kovach, SJ, Fischer, AC, Katzman, PJ, Salloum, RM, Ettinghausen, SE, Madeb, R & Koniaris, L 2006, 'Inflammatory myofibroblastic tumors', Journal of Surgical Oncology, vol. 94, no. 5, pp. 385-391. https://doi.org/10.1002/jso.20516
Kovach SJ, Fischer AC, Katzman PJ, Salloum RM, Ettinghausen SE, Madeb R et al. Inflammatory myofibroblastic tumors. Journal of Surgical Oncology. 2006 Oct 1;94(5):385-391. https://doi.org/10.1002/jso.20516
Kovach, Stephen J. ; Fischer, Anne C. ; Katzman, Philip J. ; Salloum, Rabih M. ; Ettinghausen, Stephen E. ; Madeb, Ralph ; Koniaris, Leonidas. / Inflammatory myofibroblastic tumors. In: Journal of Surgical Oncology. 2006 ; Vol. 94, No. 5. pp. 385-391.
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