Inflammatory Myofibroblastic Tumors of the Genitourinary Tract-Single Entity or Continuum?

Liang Cheng, Stephanie R. Foster, Gregory T. MacLennan, Antonio Lopez-Beltran, Shaobo Zhang, Rodolfo Montironi

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Purpose: Inflammatory myofibroblastic tumor of the genitourinary tract is a spindled soft tissue lesion that is often mistaken for sarcoma. These tumors have been described in numerous sites in the body and have been assigned many names. The relationship between inflammatory myofibroblastic tumor and other morphologically similar entities has been a long-standing source of controversy. We investigated whether inflammatory myofibroblastic tumors in adults and children are the same entity, and whether inflammatory myofibroblastic tumor is part of a biological spectrum that includes benign and malignant entities at opposite ends. Materials and Methods: We performed an extensive review of the literature. Results: The literature suggests that with evidence of anaplastic lymphoma kinase rearrangement and expression, the lesion is neoplastic rather than reactive, differentiating it from previously described lesions. Conclusions: Inflammatory myofibroblastic tumor of the genitourinary tract should be considered a neoplasm of uncertain malignant potential, and routine surveillance and close clinical followup are recommended. Aggressive therapy (radical cystectomy, radiation or chemotherapy) is unwarranted given the indolent and often benign clinical course for the majority of cases. To understand the diagnostic and prognostic implications future emphasis should be placed on the link between genetic abnormalities, and clinical course, therapeutic response and ultimate outcome.

Original languageEnglish
Pages (from-to)1235-1240
Number of pages6
JournalJournal of Urology
Volume180
Issue number4
DOIs
StatePublished - Oct 2008

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Neoplasms
Cystectomy
Sarcoma
Names
Radiation
Drug Therapy
Therapeutics

Keywords

  • carcinosarcoma
  • immunohistochemistry
  • sarcoma
  • soft tissue neoplasms
  • urinary bladder

ASJC Scopus subject areas

  • Urology

Cite this

Inflammatory Myofibroblastic Tumors of the Genitourinary Tract-Single Entity or Continuum? / Cheng, Liang; Foster, Stephanie R.; MacLennan, Gregory T.; Lopez-Beltran, Antonio; Zhang, Shaobo; Montironi, Rodolfo.

In: Journal of Urology, Vol. 180, No. 4, 10.2008, p. 1235-1240.

Research output: Contribution to journalArticle

Cheng, Liang ; Foster, Stephanie R. ; MacLennan, Gregory T. ; Lopez-Beltran, Antonio ; Zhang, Shaobo ; Montironi, Rodolfo. / Inflammatory Myofibroblastic Tumors of the Genitourinary Tract-Single Entity or Continuum?. In: Journal of Urology. 2008 ; Vol. 180, No. 4. pp. 1235-1240.
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