Influence of age on the sensitivity of the rat to streptozotocin

P. Masiello, Anna De Paoli-Roach, E. Bergamini

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The relationship between age and sensitivity to the diabetogenic effect of streptozotocin was investigated. Changes in the serum levels of several parameters (glucose, immunoreactive insulin, lipids), as well as changes of the pancreatic insulin content were monitored at 2, 4, 8, 24 and 48 h after the intravenous administration of different doses of streptozotocin in rats of various weights. Different concentrations of blood glucose and lipid and different amounts of pancreatic immunoreactive insulin could be found in rats of different ages 24 and 48 h after the injection of the same dose of the drug (in mg/kg body weight). Also, age-dependent changes of serum immunoreactive insulin could be observed as early as 4 h after streptozotocin administration. All these changes indicate that the sensitivity of the rat to the diabetogenic effect of streptozotocin is inversely related to the age of the animals. Most likely, age-dependent pancreatic factors have an important role. In fact, the changes of the minimum dose of streptozotocin required to cause diabetes in rats of different weights closely parallel the age-related changes of the total immunoreactive insulin content of the pancreas of the intact rats. The role of other age-related factors which may influence the effectiveness of streptozotocin action is briefly discussed.

Original languageEnglish (US)
Pages (from-to)262-274
Number of pages13
JournalHormone Research
Volume11
Issue number5
StatePublished - 1979
Externally publishedYes

Fingerprint

Streptozocin
Insulin
Lipids
Weights and Measures
Age Factors
Serum
Intravenous Administration
Blood Glucose
Pancreas
Body Weight
Glucose
Injections
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Endocrinology

Cite this

Influence of age on the sensitivity of the rat to streptozotocin. / Masiello, P.; De Paoli-Roach, Anna; Bergamini, E.

In: Hormone Research, Vol. 11, No. 5, 1979, p. 262-274.

Research output: Contribution to journalArticle

Masiello, P, De Paoli-Roach, A & Bergamini, E 1979, 'Influence of age on the sensitivity of the rat to streptozotocin', Hormone Research, vol. 11, no. 5, pp. 262-274.
Masiello, P. ; De Paoli-Roach, Anna ; Bergamini, E. / Influence of age on the sensitivity of the rat to streptozotocin. In: Hormone Research. 1979 ; Vol. 11, No. 5. pp. 262-274.
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