Influence of catecholestradiol on short-lived corpora lutea in beef cows

M. L. Day, S. G. Kurz, Kenneth Nephew, M. D. Wright, Y. Hu, S. P. Ford, W. F. Pope

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The influence of intrauterine administration of catecholestradiol (4-hydroxylated estradiol) on lifespan of the initial postpartum corpus luteum was evaluated in suckled beef cows. In experiment 1, postpartum cows (n=23) were untreated (CONTROL) or received intrauterine infusions (0700 and 1700 hr) of either vehicle (SAL) or catecholestradiol (CATE; 4 μg) from day 15 to 22 (day 0 = parturition). Blood samples were collected three times weekly (day 15 to 100) and analyzed for progesterone. In experiment 2, cows received twice daily intrauterine infusions of either vehicle (n=18), or catecholestradiol (n=19), from day 25 ± .5 to day 30 ± .5. Following the final infusion, calves were temporarily weaned from all cows for 48 hr. At the end of the 48 hr weaning period, cows in each infusion group received either an i.m. injection of 1,000 IU hCG (SAL+hCG, n=9; CATE+hCG, n=9) or no further treatment (SAL, n=9; CATE, n=10). Blood samples were collected daily for 21 d following calf removal and 3 times weekly through 100 d postpartum. In both experiments, the initial postpartum elevation in peripheral progesterone concentrations was characterized as either a short (8 d) luteal phase. In experiment 1, postpartum anestrous interval (60 ± 3.4 d) and incidence of short luteal phases (77%) were similar among CONTROL, SAL and CATE treatments. In experiment 2, luteal phases were induced within 10 d of onset of weaning in 90, 100, 56 and 60% of cows in SAL+hCG, CATE+hCG, SAL and CATE treatments, respectively. The incidence of attenuated increases in progesterone, indicative of short luteal phases was markedly lower (P

Original languageEnglish (US)
Pages (from-to)95-102
Number of pages8
JournalDomestic Animal Endocrinology
Volume10
Issue number2
DOIs
StatePublished - 1993
Externally publishedYes

Fingerprint

human chorionic gonadotropin
Corpus Luteum
beef cows
corpus luteum
Postpartum Period
Luteal Phase
intrauterine administration
cows
Progesterone
progesterone
Weaning
weaning
calves
postpartum interval
incidence
Incidence
blood
estradiol
Estradiol
Therapeutics

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Endocrinology
  • veterinary(all)

Cite this

Influence of catecholestradiol on short-lived corpora lutea in beef cows. / Day, M. L.; Kurz, S. G.; Nephew, Kenneth; Wright, M. D.; Hu, Y.; Ford, S. P.; Pope, W. F.

In: Domestic Animal Endocrinology, Vol. 10, No. 2, 1993, p. 95-102.

Research output: Contribution to journalArticle

Day, M. L. ; Kurz, S. G. ; Nephew, Kenneth ; Wright, M. D. ; Hu, Y. ; Ford, S. P. ; Pope, W. F. / Influence of catecholestradiol on short-lived corpora lutea in beef cows. In: Domestic Animal Endocrinology. 1993 ; Vol. 10, No. 2. pp. 95-102.
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abstract = "The influence of intrauterine administration of catecholestradiol (4-hydroxylated estradiol) on lifespan of the initial postpartum corpus luteum was evaluated in suckled beef cows. In experiment 1, postpartum cows (n=23) were untreated (CONTROL) or received intrauterine infusions (0700 and 1700 hr) of either vehicle (SAL) or catecholestradiol (CATE; 4 μg) from day 15 to 22 (day 0 = parturition). Blood samples were collected three times weekly (day 15 to 100) and analyzed for progesterone. In experiment 2, cows received twice daily intrauterine infusions of either vehicle (n=18), or catecholestradiol (n=19), from day 25 ± .5 to day 30 ± .5. Following the final infusion, calves were temporarily weaned from all cows for 48 hr. At the end of the 48 hr weaning period, cows in each infusion group received either an i.m. injection of 1,000 IU hCG (SAL+hCG, n=9; CATE+hCG, n=9) or no further treatment (SAL, n=9; CATE, n=10). Blood samples were collected daily for 21 d following calf removal and 3 times weekly through 100 d postpartum. In both experiments, the initial postpartum elevation in peripheral progesterone concentrations was characterized as either a short (8 d) luteal phase. In experiment 1, postpartum anestrous interval (60 ± 3.4 d) and incidence of short luteal phases (77{\%}) were similar among CONTROL, SAL and CATE treatments. In experiment 2, luteal phases were induced within 10 d of onset of weaning in 90, 100, 56 and 60{\%} of cows in SAL+hCG, CATE+hCG, SAL and CATE treatments, respectively. The incidence of attenuated increases in progesterone, indicative of short luteal phases was markedly lower (P",
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