Influence of filgrastim (granulocyte colony-stimulating factor) on human immunodeficiency virus type 1 RNA in patients with cytomegalovirus retinitis

Studies of Ocular Complications of AIDS (SOCA) Research Group

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Filgrastim, or granulocyte colony-stimulating factor, reverses neutropenia associated with human immunodeficiency virus type 1 (HIV-1) and cytomegalovirus (CMV) infections. During a trial of anti-CMV retinitis therapies coadministered with antiretroviral therapy, 2-4 plasma specimens of HIV-1 RNA were collected from 36 HIV-1-infected patients receiving filgrastim to prevent neutropenia and from 36 patients not receiving filgrastim. For both groups, the crude mean and mean rate of change of HIV-1 log10 RNA levels were similar. Adjustment for covariates (CD4+ T cell lymphocytes, virus load at enrollment, level of neutropenia and antiretroviral therapy [mainly non-highly active antiretroviral therapy], and anti-CMV therapy during follow-up) resulted in a mean log10 HIV-1 RNA level for individuals receiving filgrastim versus those not receiving the drug of 5.11 versus 4.87 (P = .12) and respective log mean rates of change per month of -0.08 versus -0.21 (P = .08). This latter difference has borderline statistical significance, which suggests that filgrastim may reduce the decline of HIV-1 RNA loads.

Original languageEnglish (US)
Pages (from-to)1013-1018
Number of pages6
JournalJournal of Infectious Diseases
Issue number7
StatePublished - Oct 1 2002


ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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