Influence of secobarbital and α-chloralose, and of vagal and sympathetic interruption, on left ventricular activation after acute coronary artery occlusion in the dog

R. Ruffy, D. E. Lovelace, S. B. Knoebel, D. P. Zipes

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

The purpose of this study was to examine the effect of secobarbital vs. α-chloralose anesthesia, and of tonic autonomic influence, upon ischemia-induced subepicardial and subendocardial bipolar electrogram changes during acute coronary artery occlusion in the open-chest dog. We found that the degree of bipolar electrogram alterations for similar reductions of regional myocardial blood flow was less in dogs anesthetized with α-chloralose than in those anesthetized with secobarbital. We also noted greater electrogram changes when the sympathetic system was unopposed by the vagus nerves. Finally, this study demonstrates the reproducibility of ischemia-induced changes in bipolar electrograms during serial, short term, acute coronary artery occlusions.

Original languageEnglish (US)
Pages (from-to)884-894
Number of pages11
JournalCirculation research
Volume48
Issue number6
DOIs
StatePublished - Jan 1 1981

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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