Influence of shock strength and timing on induction of ventricular arrhythmias in dogs

N. Shibata, P. S. Chen, E. G. Dixon, P. D. Wolf, N. D. Danieley, W. M. Smith, R. E. Ideker

Research output: Contribution to journalArticle

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Abstract

We delivered strong shocks via electrodes on the left ventricular apex and the right atrium in seven dogs during the T wave of atrial pacing while recordings were made from 56 epicardial electrodes. After shocks that induced arrhythmias were given, the earliest activation occurred in the middle of the ventricles for lower-energy shocks and in the base for higher-energy shocks. For shocks late in the vulnerable period, activation was recorded soon after the shock, whereas for shocks early in the vulnerable period activation was not recorded for a mean of 70 ma (±17 ms SD) after the shock. We also gave 1-J shocks during right and left ventricular pacing. For shocks early in the vulnerable period, activation initiating fibrillation arose in a focal pattern from the paced region. For shocks during the midportion of the vulnerable period, fibrillation arose by two leading circle reentrant loops rotating in opposite directions, one on the left and the other on the right ventricule. For shocks at the end of the vulnerable period, the two reentrant loops fused on the side of the heart opposite the pacing site to again form a single focal activation pattern. Thus the initial activation patterns of arrhythmias initiated by shocks, the time from the shock until earliest postshock activation, and the site of earliest postshock activation are strongly influenced by the coupling interval and strength of the shock.

Original languageEnglish (US)
Pages (from-to)24/4
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume255
Issue number4
StatePublished - Jan 1 1988

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Cardiac Arrhythmias
Shock
Dogs
Electrodes
Heart Atria

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Shibata, N., Chen, P. S., Dixon, E. G., Wolf, P. D., Danieley, N. D., Smith, W. M., & Ideker, R. E. (1988). Influence of shock strength and timing on induction of ventricular arrhythmias in dogs. American Journal of Physiology - Heart and Circulatory Physiology, 255(4), 24/4.

Influence of shock strength and timing on induction of ventricular arrhythmias in dogs. / Shibata, N.; Chen, P. S.; Dixon, E. G.; Wolf, P. D.; Danieley, N. D.; Smith, W. M.; Ideker, R. E.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 255, No. 4, 01.01.1988, p. 24/4.

Research output: Contribution to journalArticle

Shibata, N, Chen, PS, Dixon, EG, Wolf, PD, Danieley, ND, Smith, WM & Ideker, RE 1988, 'Influence of shock strength and timing on induction of ventricular arrhythmias in dogs', American Journal of Physiology - Heart and Circulatory Physiology, vol. 255, no. 4, pp. 24/4.
Shibata, N. ; Chen, P. S. ; Dixon, E. G. ; Wolf, P. D. ; Danieley, N. D. ; Smith, W. M. ; Ideker, R. E. / Influence of shock strength and timing on induction of ventricular arrhythmias in dogs. In: American Journal of Physiology - Heart and Circulatory Physiology. 1988 ; Vol. 255, No. 4. pp. 24/4.
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