Influence of the Autonomic Nervous System on the Genesis of Cardiac Arrhythmias

DOUGLAS P. ZIPES, MICHAEL J. BARBER, NOBUHIRO TAKAHASHI, ROBERT F. GILMOUR

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Abstract

The purpose of this report is to present a brief overview of the concepts concerned with the potential effects of the autonomic nervous system on the genesis of cardiac arrhythmias. First, we present data indicating the functional importance of presynaptic and postsynaptic vagal modulation of adrenergic neurotransmission on electrical activity in sinus and A-V nodes, and contractile activity of canine cardiac Purkinje fibers. Second, we indicate the possible intraventricular adrenergic and vagal pathways to the ventricles, suggesting that sympathetic fibers travel in the epicardium while vagal fibers appear to cross the A-V groove in the epicardium but then take an intramural route for part of their course. Finally, we demonstrate that a lesion such as a myocardial infarction can interrupt neural fibers traveling through the infarction to affect noninfarcted myocardium distal to the infarction. These factors may play a role in the genesis of some cardiac arrhythmias.

Original languageEnglish (US)
Pages (from-to)1210-1220
Number of pages11
JournalPacing and Clinical Electrophysiology
Volume6
Issue number5
DOIs
StatePublished - Sep 1983

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Keywords

  • autonomic nervous system
  • cardiac arrhythmias
  • myocardial infarction
  • neurotransmission

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

ZIPES, DOUGLAS. P., BARBER, MICHAEL. J., TAKAHASHI, NOBUHIRO., & GILMOUR, ROBERT. F. (1983). Influence of the Autonomic Nervous System on the Genesis of Cardiac Arrhythmias. Pacing and Clinical Electrophysiology, 6(5), 1210-1220. https://doi.org/10.1111/j.1540-8159.1983.tb04459.x