Influence of the autonomic nervous system on the genesis of cardiac arrhythmias.

D. P. Zipes, M. J. Barber, N. Takahashi, R. F. Gilmour

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

The purpose of this report is to present a brief overview of the concepts concerned with the potential effects of the autonomic nervous system on the genesis of cardiac arrhythmias. First, we present data indicating the functional importance of presynaptic and postsynaptic vagal modulation of adrenergic neurotransmission on electrical activity in sinus and A-V nodes, and contractile activity of canine cardiac Purkinje fibers. Second, we indicate the possible intraventricular adrenergic and vagal pathways to the ventricles, suggesting that sympathetic fibers travel in the epicardium while vagal fibers appear to cross the A-V groove in the epicardium but then take an intramural route for part of their course. Finally, we demonstrate that a lesion such as a myocardial infarction can interrupt neural fibers traveling through the infarction to affect noninfarcted myocardium distal to the infarction. These factors may play a role in the genesis of some cardiac arrhythmias.

Original languageEnglish
Pages (from-to)1210-1220
Number of pages11
JournalPACE - Pacing and Clinical Electrophysiology
Volume6
Issue number5 Pt 2
StatePublished - Sep 1983
Externally publishedYes

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Pericardium
Autonomic Nervous System
Adrenergic Agents
Infarction
Cardiac Arrhythmias
Purkinje Fibers
Adrenergic Fibers
Atrioventricular Node
Synaptic Transmission
Canidae
Myocardium
Myocardial Infarction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Zipes, D. P., Barber, M. J., Takahashi, N., & Gilmour, R. F. (1983). Influence of the autonomic nervous system on the genesis of cardiac arrhythmias. PACE - Pacing and Clinical Electrophysiology, 6(5 Pt 2), 1210-1220.

Influence of the autonomic nervous system on the genesis of cardiac arrhythmias. / Zipes, D. P.; Barber, M. J.; Takahashi, N.; Gilmour, R. F.

In: PACE - Pacing and Clinical Electrophysiology, Vol. 6, No. 5 Pt 2, 09.1983, p. 1210-1220.

Research output: Contribution to journalArticle

Zipes, DP, Barber, MJ, Takahashi, N & Gilmour, RF 1983, 'Influence of the autonomic nervous system on the genesis of cardiac arrhythmias.', PACE - Pacing and Clinical Electrophysiology, vol. 6, no. 5 Pt 2, pp. 1210-1220.
Zipes, D. P. ; Barber, M. J. ; Takahashi, N. ; Gilmour, R. F. / Influence of the autonomic nervous system on the genesis of cardiac arrhythmias. In: PACE - Pacing and Clinical Electrophysiology. 1983 ; Vol. 6, No. 5 Pt 2. pp. 1210-1220.
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