Influence of TSPO genotype on 11C-PBR28 standardized uptake values

Karmen K. Yoder, Kwangsik Nho, Shannon L. Risacher, Sungeun Kim, Li Shen, Andrew J. Saykin

Research output: Contribution to journalArticle

46 Scopus citations

Abstract

11C-PBR28 binds to the high-affinity state of the translocator protein 18 kDa (TSPO). A single-nucleotide polymorphism (rs6971) within the human TSPO gene determines the affinity state of the TSPO. The rs6971 genotype determines whether individuals express the high-, low-, or mixed-affinity phenotype of TSPO. The rs6971 genotype corresponds to in vivo 11C-PBR28 binding, as measured quantitatively by total volume of distribution. However, it is not known whether standardized uptake value (SUV) can detect differences in brain 11C-PBR28 uptake by TSPO genotype. Methods: Thirty-two older adults (71.8 ± 7.94 y old) underwent 11C-PBR28 PET scanning; rs6971 genotype was imputed after genomewide genotyping. SUV was extracted for several brain regions. The sample included 19 C/C carriers (high-affinity phenotype), 12 T/C carriers (mixedaffinity), and 1 T/T carrier (low-affinity) for rs6971. Results: SUV was 30% lower in T/C subjects than in C/C subjects. Conclusion: The results indicate that brain 11C-PBR28 SUV is sensitive to TSPO genotype. COPYRIGHT

Original languageEnglish (US)
Pages (from-to)1320-1322
Number of pages3
JournalJournal of Nuclear Medicine
Volume54
Issue number8
DOIs
StatePublished - Aug 1 2013

Keywords

  • C-PBR28
  • Genotype
  • Positron emission tomography
  • TSPO

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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