Inherited epilepsies

Larry Walsh, Dani McCandless

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Epilepsy may be acquired or inherited. At least one half of epilepsy is genetic in origin; this figure is likely higher in children regardless of whether seizures are generalized or partial. Inherited epilepsies are classified as benign, cryptogenic, or symptomatic depending on associated clinical, electrographic, and neuroimaging features. To date, genetic mutations in the idiopathic inherited epilepsies affect channel function within the central nervous system; genes underlying symptomatic epilepsies are more heterogeneous. Accurate diagnosis of an inherited epilepsy syndrome provides useful prognostic information; it also may help guide diagnostic evaluation, including request for specific gene testing. In the near future, the relationship between genetic defect and response to specific anticonvulsants may also be better defined.

Original languageEnglish
Pages (from-to)165-176
Number of pages12
JournalSeminars in Pediatric Neurology
Volume8
Issue number3
StatePublished - 2001

Fingerprint

Epilepsy
Neuroimaging
Anticonvulsants
Genes
Seizures
Central Nervous System
Mutation

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Walsh, L., & McCandless, D. (2001). Inherited epilepsies. Seminars in Pediatric Neurology, 8(3), 165-176.

Inherited epilepsies. / Walsh, Larry; McCandless, Dani.

In: Seminars in Pediatric Neurology, Vol. 8, No. 3, 2001, p. 165-176.

Research output: Contribution to journalArticle

Walsh, L & McCandless, D 2001, 'Inherited epilepsies', Seminars in Pediatric Neurology, vol. 8, no. 3, pp. 165-176.
Walsh, Larry ; McCandless, Dani. / Inherited epilepsies. In: Seminars in Pediatric Neurology. 2001 ; Vol. 8, No. 3. pp. 165-176.
@article{a587e337c9b94f8c8b1dca3efa389237,
title = "Inherited epilepsies",
abstract = "Epilepsy may be acquired or inherited. At least one half of epilepsy is genetic in origin; this figure is likely higher in children regardless of whether seizures are generalized or partial. Inherited epilepsies are classified as benign, cryptogenic, or symptomatic depending on associated clinical, electrographic, and neuroimaging features. To date, genetic mutations in the idiopathic inherited epilepsies affect channel function within the central nervous system; genes underlying symptomatic epilepsies are more heterogeneous. Accurate diagnosis of an inherited epilepsy syndrome provides useful prognostic information; it also may help guide diagnostic evaluation, including request for specific gene testing. In the near future, the relationship between genetic defect and response to specific anticonvulsants may also be better defined.",
author = "Larry Walsh and Dani McCandless",
year = "2001",
language = "English",
volume = "8",
pages = "165--176",
journal = "Seminars in Pediatric Neurology",
issn = "1071-9091",
publisher = "W.B. Saunders Ltd",
number = "3",

}

TY - JOUR

T1 - Inherited epilepsies

AU - Walsh, Larry

AU - McCandless, Dani

PY - 2001

Y1 - 2001

N2 - Epilepsy may be acquired or inherited. At least one half of epilepsy is genetic in origin; this figure is likely higher in children regardless of whether seizures are generalized or partial. Inherited epilepsies are classified as benign, cryptogenic, or symptomatic depending on associated clinical, electrographic, and neuroimaging features. To date, genetic mutations in the idiopathic inherited epilepsies affect channel function within the central nervous system; genes underlying symptomatic epilepsies are more heterogeneous. Accurate diagnosis of an inherited epilepsy syndrome provides useful prognostic information; it also may help guide diagnostic evaluation, including request for specific gene testing. In the near future, the relationship between genetic defect and response to specific anticonvulsants may also be better defined.

AB - Epilepsy may be acquired or inherited. At least one half of epilepsy is genetic in origin; this figure is likely higher in children regardless of whether seizures are generalized or partial. Inherited epilepsies are classified as benign, cryptogenic, or symptomatic depending on associated clinical, electrographic, and neuroimaging features. To date, genetic mutations in the idiopathic inherited epilepsies affect channel function within the central nervous system; genes underlying symptomatic epilepsies are more heterogeneous. Accurate diagnosis of an inherited epilepsy syndrome provides useful prognostic information; it also may help guide diagnostic evaluation, including request for specific gene testing. In the near future, the relationship between genetic defect and response to specific anticonvulsants may also be better defined.

UR - http://www.scopus.com/inward/record.url?scp=0034824285&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034824285&partnerID=8YFLogxK

M3 - Article

C2 - 11575846

AN - SCOPUS:0034824285

VL - 8

SP - 165

EP - 176

JO - Seminars in Pediatric Neurology

JF - Seminars in Pediatric Neurology

SN - 1071-9091

IS - 3

ER -