Inherited forms of bladder cancer: A review of Lynch syndrome and other inherited conditions

Aaron Phelan, Antonio Lopez-Beltran, Rodolfo Montironi, Shaobo Zhang, Maria R. Raspollini, Monica Cheng, Hristos Kaimakliotis, Michael Koch, Liang Cheng

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

Environmental factors that play a role in the urothelial carcinogenesis have been well characterized. Current research is continuously exploring potential heritable forms of bladder cancer. Lynch syndrome is a well-known inheritable disease that increases the risk for a variety of cancers, including urothelial carcinomas. Screening of patients with known Lynch syndrome is important to evaluate for development of new primary tumors. Further study may provide more information on what level of follow-up each patient needs. Recent data suggest that mismatch repair mutations confer a greater risk for urothelial cancer. Additional large patient series as well as advancement of molecular testing may provide triage for Lynch syndrome patients in regards to the frequency and type of screening best suited for individual patient.

Original languageEnglish (US)
Pages (from-to)277-290
Number of pages14
JournalFuture Oncology
Volume14
Issue number3
DOIs
StatePublished - Feb 1 2018

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Keywords

  • bladder cancer
  • genetic susceptibility
  • Lynch syndrome
  • microsatellite instability
  • mismatch repair deficiency
  • molecular genetics
  • upper urinary tract cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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