Inhibiting HDAC for human hematopoietic stem cell expansion

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

In this issue of the JCI, Chaurasia and colleagues report an impressive ex vivo expansion of HSCs from human cord blood (CB) using cytokines and altering epigenetic modifications. The application of this protocol provides information that has potential for clinical consideration. The enhanced expansion of CB HSCs is a substantial advance over recent work from the Chaurasia and Hoffman group, in which ex vivo production of human erythroid progenitor cells from CB was promoted by chromatin modification. Moreover, this study takes advantage of information from the rapidly emerging, but not yet fully elucidated, field of epigenetics.

Original languageEnglish
Pages (from-to)2365-2368
Number of pages4
JournalJournal of Clinical Investigation
Volume124
Issue number6
DOIs
StatePublished - Jun 2 2014

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Hematopoietic Stem Cells
Fetal Blood
Epigenomics
Erythroid Precursor Cells
Chromatin
Cytokines

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Inhibiting HDAC for human hematopoietic stem cell expansion. / Broxmeyer, Hal.

In: Journal of Clinical Investigation, Vol. 124, No. 6, 02.06.2014, p. 2365-2368.

Research output: Contribution to journalArticle

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