Inhibition of CD1d1-mediated antigen presentation by the vaccinia virus B1R and H5R molecules

Tonja J Roberts Webb, Roberta A. Litavecz, Masood A. Khan, Wenjun Du, Jacquelyn Gervay-Hague, Gourapura J. Renukaradhya, Randy Brutkiewicz

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Vaccinia virus (VV) has been most commonly used as the vaccine to protect individuals against the causative agent of smallpox (variola virus), but it also uses a number of strategies meant to evade or blunt the host's antiviral immune response. Natural killer T (NKT) cells are a subset of immunoregulatory CD1d-restricted T lymphocytes believed to bridge the innate and adaptive immune responses. It is shown here that the VV-encoded molecules, B1R and H5R, play a role in the ability of VV to inhibit CD1d-mediated antigen presentation to NKT cells. These are the first poxvirus-encoded molecules identified that can play such a role in the evasion of an important component of the innate immune response.

Original languageEnglish
Pages (from-to)2595-2600
Number of pages6
JournalEuropean Journal of Immunology
Volume36
Issue number10
DOIs
StatePublished - Oct 2006

Fingerprint

Vaccinia virus
Antigen Presentation
Variola virus
Natural Killer T-Cells
Innate Immunity
CD1d Antigen
Poxviridae
T-Lymphocyte Subsets
Adaptive Immunity
Antiviral Agents
Vaccines
T-Lymphocytes

Keywords

  • Antigen presentation
  • CD1d
  • Immune evasion
  • NKT cells
  • Vaccinia virus

ASJC Scopus subject areas

  • Immunology

Cite this

Webb, T. J. R., Litavecz, R. A., Khan, M. A., Du, W., Gervay-Hague, J., Renukaradhya, G. J., & Brutkiewicz, R. (2006). Inhibition of CD1d1-mediated antigen presentation by the vaccinia virus B1R and H5R molecules. European Journal of Immunology, 36(10), 2595-2600. https://doi.org/10.1002/eji.200636024

Inhibition of CD1d1-mediated antigen presentation by the vaccinia virus B1R and H5R molecules. / Webb, Tonja J Roberts; Litavecz, Roberta A.; Khan, Masood A.; Du, Wenjun; Gervay-Hague, Jacquelyn; Renukaradhya, Gourapura J.; Brutkiewicz, Randy.

In: European Journal of Immunology, Vol. 36, No. 10, 10.2006, p. 2595-2600.

Research output: Contribution to journalArticle

Webb, TJR, Litavecz, RA, Khan, MA, Du, W, Gervay-Hague, J, Renukaradhya, GJ & Brutkiewicz, R 2006, 'Inhibition of CD1d1-mediated antigen presentation by the vaccinia virus B1R and H5R molecules', European Journal of Immunology, vol. 36, no. 10, pp. 2595-2600. https://doi.org/10.1002/eji.200636024
Webb TJR, Litavecz RA, Khan MA, Du W, Gervay-Hague J, Renukaradhya GJ et al. Inhibition of CD1d1-mediated antigen presentation by the vaccinia virus B1R and H5R molecules. European Journal of Immunology. 2006 Oct;36(10):2595-2600. https://doi.org/10.1002/eji.200636024
Webb, Tonja J Roberts ; Litavecz, Roberta A. ; Khan, Masood A. ; Du, Wenjun ; Gervay-Hague, Jacquelyn ; Renukaradhya, Gourapura J. ; Brutkiewicz, Randy. / Inhibition of CD1d1-mediated antigen presentation by the vaccinia virus B1R and H5R molecules. In: European Journal of Immunology. 2006 ; Vol. 36, No. 10. pp. 2595-2600.
@article{1c9e1aab33c8489481b0226dceb78150,
title = "Inhibition of CD1d1-mediated antigen presentation by the vaccinia virus B1R and H5R molecules",
abstract = "Vaccinia virus (VV) has been most commonly used as the vaccine to protect individuals against the causative agent of smallpox (variola virus), but it also uses a number of strategies meant to evade or blunt the host's antiviral immune response. Natural killer T (NKT) cells are a subset of immunoregulatory CD1d-restricted T lymphocytes believed to bridge the innate and adaptive immune responses. It is shown here that the VV-encoded molecules, B1R and H5R, play a role in the ability of VV to inhibit CD1d-mediated antigen presentation to NKT cells. These are the first poxvirus-encoded molecules identified that can play such a role in the evasion of an important component of the innate immune response.",
keywords = "Antigen presentation, CD1d, Immune evasion, NKT cells, Vaccinia virus",
author = "Webb, {Tonja J Roberts} and Litavecz, {Roberta A.} and Khan, {Masood A.} and Wenjun Du and Jacquelyn Gervay-Hague and Renukaradhya, {Gourapura J.} and Randy Brutkiewicz",
year = "2006",
month = "10",
doi = "10.1002/eji.200636024",
language = "English",
volume = "36",
pages = "2595--2600",
journal = "European Journal of Immunology",
issn = "0014-2980",
publisher = "Wiley-VCH Verlag",
number = "10",

}

TY - JOUR

T1 - Inhibition of CD1d1-mediated antigen presentation by the vaccinia virus B1R and H5R molecules

AU - Webb, Tonja J Roberts

AU - Litavecz, Roberta A.

AU - Khan, Masood A.

AU - Du, Wenjun

AU - Gervay-Hague, Jacquelyn

AU - Renukaradhya, Gourapura J.

AU - Brutkiewicz, Randy

PY - 2006/10

Y1 - 2006/10

N2 - Vaccinia virus (VV) has been most commonly used as the vaccine to protect individuals against the causative agent of smallpox (variola virus), but it also uses a number of strategies meant to evade or blunt the host's antiviral immune response. Natural killer T (NKT) cells are a subset of immunoregulatory CD1d-restricted T lymphocytes believed to bridge the innate and adaptive immune responses. It is shown here that the VV-encoded molecules, B1R and H5R, play a role in the ability of VV to inhibit CD1d-mediated antigen presentation to NKT cells. These are the first poxvirus-encoded molecules identified that can play such a role in the evasion of an important component of the innate immune response.

AB - Vaccinia virus (VV) has been most commonly used as the vaccine to protect individuals against the causative agent of smallpox (variola virus), but it also uses a number of strategies meant to evade or blunt the host's antiviral immune response. Natural killer T (NKT) cells are a subset of immunoregulatory CD1d-restricted T lymphocytes believed to bridge the innate and adaptive immune responses. It is shown here that the VV-encoded molecules, B1R and H5R, play a role in the ability of VV to inhibit CD1d-mediated antigen presentation to NKT cells. These are the first poxvirus-encoded molecules identified that can play such a role in the evasion of an important component of the innate immune response.

KW - Antigen presentation

KW - CD1d

KW - Immune evasion

KW - NKT cells

KW - Vaccinia virus

UR - http://www.scopus.com/inward/record.url?scp=33750227454&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33750227454&partnerID=8YFLogxK

U2 - 10.1002/eji.200636024

DO - 10.1002/eji.200636024

M3 - Article

VL - 36

SP - 2595

EP - 2600

JO - European Journal of Immunology

JF - European Journal of Immunology

SN - 0014-2980

IS - 10

ER -