Inhibition of hepatic lipogenesis by 2-tetradecylglycidic acid

Sylvia A. McCune, Takahide Nomura, Robert Harris

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

2-Tetradecylglycidic acid (TDGA), a hypoglycemic agent, has been found to be a very effective inhibitor of de novo fatty acid synthesis by isolated hepatocytes. A comparison was made between the effectiveness of TDGA and 5-(tetradecyloxy)-2-furoic acid (TOFA), a hypolipidemic agent, on the metabolic processes of isolated hepatocytes. These compounds are structurally related and both inhibit fatty acid synthesis; however, they have opposite effects from each other on the oxidation and esterification of fatty acids. TDGA inhibits whereas TOFA stimulates fatty acid oxidation. TDGA stimulates whereas TOFA inhibits fatty acid esterification.

Original languageEnglish
Pages (from-to)880-882
Number of pages3
JournalLipids
Volume14
Issue number10
DOIs
StatePublished - Oct 1979

Fingerprint

Lipogenesis
lipogenesis
Fatty Acids
liver
Liver
acids
Esterification
fatty acids
Hepatocytes
esterification
Hypolipidemic Agents
hepatocytes
antilipemic agents
Oxidation
hypoglycemic agents
Hypoglycemic Agents
synthesis
beta oxidation
2-tetradecylglycidic acid
oxidation

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Food Science

Cite this

Inhibition of hepatic lipogenesis by 2-tetradecylglycidic acid. / McCune, Sylvia A.; Nomura, Takahide; Harris, Robert.

In: Lipids, Vol. 14, No. 10, 10.1979, p. 880-882.

Research output: Contribution to journalArticle

McCune, Sylvia A. ; Nomura, Takahide ; Harris, Robert. / Inhibition of hepatic lipogenesis by 2-tetradecylglycidic acid. In: Lipids. 1979 ; Vol. 14, No. 10. pp. 880-882.
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