Inhibition of intracranial glioma growth by endometrial regenerative cells

Xiaodi Han, Xiaolong Meng, Zhenglian Yin, Andrea Rogers, Jie Zhong, Paul Rillema, James A. Jackson, Thomas E. Ichim, Boris Minev, Ewa Carrier, Amit N. Patel, Michael P. Murphy, Wei Ping Min, Neil H. Riordan

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

Animal studies have demonstrated that selective tropism of mesenchymal stem cells (MSC) for glioma may be used as a means of selective delivery of cytotoxic payloads. Endometrial Regenerative Cells (ERC) are a population of mesenchymal-like cells which possesse pluripotent differentiation capacity and is characterized by unique surface markers and growth factor production. In this study we sought to determine whether unmanipulated ERC would alter the growth of glioma using the aggressive C6/ LacZ7 (C6) into Sprague Dawley rat model. ERC administration by intravenous (i.v.) or intratumoral (i.t.) showed significant inhibition of glioma: volume reduction of 49% after i.v. treatment (p < 0.05), and about 46% i.t. treatment (p < 0.05). Tumor reduction was associated with inhibition of angiogenesis and reduced numbers of CD133 positive cells in the incranial tumor. Despite the angiogenic potential of ERC in the hindlimb ischemia model, these data support a paradoxical tumor inhibitory activity of ERC. Further studies are needed to determine the qualitative differences between physiological angiogenesis, which seems to be supported by ERC and tumor angiogenesis which appeared to be inhibited.

Original languageEnglish (US)
Pages (from-to)606-610
Number of pages5
JournalCell Cycle
Volume8
Issue number4
DOIs
StatePublished - Feb 15 2009

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Keywords

  • Cancer stem cells
  • Endometrial regenerative cells
  • Glioma
  • Immune
  • Mesenchymal stem cells
  • Stem cell therapy

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Developmental Biology

Cite this

Han, X., Meng, X., Yin, Z., Rogers, A., Zhong, J., Rillema, P., Jackson, J. A., Ichim, T. E., Minev, B., Carrier, E., Patel, A. N., Murphy, M. P., Min, W. P., & Riordan, N. H. (2009). Inhibition of intracranial glioma growth by endometrial regenerative cells. Cell Cycle, 8(4), 606-610. https://doi.org/10.4161/cc.8.4.7731