NSC 163501 and its hydroxy analog (αS,4S,5R) α amino 3 chloro 4 hydroxy 4,5 dihydro 5 isoxazoleacetic acid (NSC 176324) are powerful inhibitors of the utilization of L glutamine by L asparagine synthetase both in vitro and in vivo. The type of inhibition produced in vitro is concluded to be apparently competitive on the basis of graphic analysis. L glutamine in large molar excess effectively antagonizes inhibition produced by these agents; however, established inhibition is concluded to be irreversible on the basis of dialysis experiments. Attempts to demonstrate alteration of the inhibitor molecule in the act of catalysis were unsuccessful.
|Original language||English (US)|
|Number of pages||10|
|State||Published - Jan 1 1974|
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