Ingestion of Histoplasma capsulatum yeast cells inhibits the oxidative burst response of murine macrophages (Mφ's). Since protein kinase C (PKC) is believed to be an integral part of the signal transduction pathway involved in the production of reactive oxygen intermediates, we investigated the relationship between PKC activity and oxidative burst inhibition in H. capsulatum-containing murine peritoneal Mφ's. An inhibitory effect on both basal and phorbol myristate acetate-mobilized membrane PKC activities was observed in Mφ's which had ingested H. capsulatum but not latex spheres. These results suggest that one way in which H. capsulatum may disrupt the oxidative burst is through a PKC-dependent mechanism.
|Original language||English (US)|
|Number of pages||5|
|Journal||Infection and immunity|
|State||Published - Jan 1 1992|
ASJC Scopus subject areas
- Infectious Diseases