Inhibition of murine macrophage protein kinase C activity by nonviable Histoplasma capsulatum

J. E. Wolf, S. E. Massof, J. R. Sherwin, R. V. Considine

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Ingestion of Histoplasma capsulatum yeast cells inhibits the oxidative burst response of murine macrophages (Mφ's). Since protein kinase C (PKC) is believed to be an integral part of the signal transduction pathway involved in the production of reactive oxygen intermediates, we investigated the relationship between PKC activity and oxidative burst inhibition in H. capsulatum-containing murine peritoneal Mφ's. An inhibitory effect on both basal and phorbol myristate acetate-mobilized membrane PKC activities was observed in Mφ's which had ingested H. capsulatum but not latex spheres. These results suggest that one way in which H. capsulatum may disrupt the oxidative burst is through a PKC-dependent mechanism.

Original languageEnglish (US)
Pages (from-to)2683-2687
Number of pages5
JournalInfection and immunity
Volume60
Issue number7
StatePublished - Jan 1 1992

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ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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