Inhibition of murine macrophage protein kinase C activity by nonviable Histoplasma capsulatum

J. E. Wolf, S. E. Massof, J. R. Sherwin, Robert Considine

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Ingestion of Histoplasma capsulatum yeast cells inhibits the oxidative burst response of murine macrophages (Mφ's). Since protein kinase C (PKC) is believed to be an integral part of the signal transduction pathway involved in the production of reactive oxygen intermediates, we investigated the relationship between PKC activity and oxidative burst inhibition in H. capsulatum-containing murine peritoneal Mφ's. An inhibitory effect on both basal and phorbol myristate acetate-mobilized membrane PKC activities was observed in Mφ's which had ingested H. capsulatum but not latex spheres. These results suggest that one way in which H. capsulatum may disrupt the oxidative burst is through a PKC-dependent mechanism.

Original languageEnglish (US)
Pages (from-to)2683-2687
Number of pages5
JournalInfection and Immunity
Volume60
Issue number7
StatePublished - 1992
Externally publishedYes

Fingerprint

Histoplasma
Protein Kinase C
Respiratory Burst
Macrophages
Peritoneal Macrophages
Tetradecanoylphorbol Acetate
Microspheres
Signal Transduction
Membrane Proteins
Eating
Yeasts
Oxygen

ASJC Scopus subject areas

  • Immunology

Cite this

Inhibition of murine macrophage protein kinase C activity by nonviable Histoplasma capsulatum. / Wolf, J. E.; Massof, S. E.; Sherwin, J. R.; Considine, Robert.

In: Infection and Immunity, Vol. 60, No. 7, 1992, p. 2683-2687.

Research output: Contribution to journalArticle

Wolf, J. E. ; Massof, S. E. ; Sherwin, J. R. ; Considine, Robert. / Inhibition of murine macrophage protein kinase C activity by nonviable Histoplasma capsulatum. In: Infection and Immunity. 1992 ; Vol. 60, No. 7. pp. 2683-2687.
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