Inhibition of Nb2 T-lymphoma cell growth by transforming growth factor-β

E. J. Rayhel, D. A. Prentice, P. S. Tabor, W. H. Flurkey, R. W. Geib, R. F. Laherty, S. B. Schnitzer, R. Chen, J. P. Hughes

Research output: Contribution to journalArticle

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Abstract

Transforming growth factor-β (TGF-β) inhibits proliferation of Nb2 cells, a rat T lymphoma, in response to lactogens and interleukin-2. Prostaglandins may play an important role in the pathway through which TGF-β exerts its inhibitory actions, because prostaglandin E2 also inhibits proliferation of Nb2 cells, and indomethacin, an inhibitor of prostaglandin synthesis, reverses the inhibitory effects of TGF-β on Nb2 cell proliferation.

Original languageEnglish
Pages (from-to)295-298
Number of pages4
JournalBiochemical Journal
Volume253
Issue number1
StatePublished - 1988

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T-Cell Lymphoma
Cell growth
Transforming Growth Factors
Cell Proliferation
Growth
Prostaglandin Antagonists
Cell proliferation
Dinoprostone
Indomethacin
Prostaglandins
Interleukin-2
Rats
Lymphoma

ASJC Scopus subject areas

  • Biochemistry

Cite this

Rayhel, E. J., Prentice, D. A., Tabor, P. S., Flurkey, W. H., Geib, R. W., Laherty, R. F., ... Hughes, J. P. (1988). Inhibition of Nb2 T-lymphoma cell growth by transforming growth factor-β. Biochemical Journal, 253(1), 295-298.

Inhibition of Nb2 T-lymphoma cell growth by transforming growth factor-β. / Rayhel, E. J.; Prentice, D. A.; Tabor, P. S.; Flurkey, W. H.; Geib, R. W.; Laherty, R. F.; Schnitzer, S. B.; Chen, R.; Hughes, J. P.

In: Biochemical Journal, Vol. 253, No. 1, 1988, p. 295-298.

Research output: Contribution to journalArticle

Rayhel, EJ, Prentice, DA, Tabor, PS, Flurkey, WH, Geib, RW, Laherty, RF, Schnitzer, SB, Chen, R & Hughes, JP 1988, 'Inhibition of Nb2 T-lymphoma cell growth by transforming growth factor-β', Biochemical Journal, vol. 253, no. 1, pp. 295-298.
Rayhel EJ, Prentice DA, Tabor PS, Flurkey WH, Geib RW, Laherty RF et al. Inhibition of Nb2 T-lymphoma cell growth by transforming growth factor-β. Biochemical Journal. 1988;253(1):295-298.
Rayhel, E. J. ; Prentice, D. A. ; Tabor, P. S. ; Flurkey, W. H. ; Geib, R. W. ; Laherty, R. F. ; Schnitzer, S. B. ; Chen, R. ; Hughes, J. P. / Inhibition of Nb2 T-lymphoma cell growth by transforming growth factor-β. In: Biochemical Journal. 1988 ; Vol. 253, No. 1. pp. 295-298.
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