Inhibition of Nb2 T-lymphoma cell growth by transforming growth factor-β

E. J. Rayhel, D. A. Prentice, P. S. Tabor, W. H. Flurkey, R. W. Geib, R. F. Laherty, S. B. Schnitzer, R. Chen, J. P. Hughes

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7 Scopus citations

Abstract

Transforming growth factor-β (TGF-β) inhibits proliferation of Nb2 cells, a rat T lymphoma, in response to lactogens and interleukin-2. Prostaglandins may play an important role in the pathway through which TGF-β exerts its inhibitory actions, because prostaglandin E2 also inhibits proliferation of Nb2 cells, and indomethacin, an inhibitor of prostaglandin synthesis, reverses the inhibitory effects of TGF-β on Nb2 cell proliferation.

Original languageEnglish (US)
Pages (from-to)295-298
Number of pages4
JournalBiochemical Journal
Volume253
Issue number1
DOIs
StatePublished - Jan 1 1988

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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    Rayhel, E. J., Prentice, D. A., Tabor, P. S., Flurkey, W. H., Geib, R. W., Laherty, R. F., Schnitzer, S. B., Chen, R., & Hughes, J. P. (1988). Inhibition of Nb2 T-lymphoma cell growth by transforming growth factor-β. Biochemical Journal, 253(1), 295-298. https://doi.org/10.1042/bj2530295