Inhibition of osteocyte apoptosis prevents the increase in osteocytic receptor activator of nuclear factor κb Ligand (RANKL) but does not stop bone resorption or the loss of bone induced by unloading

Lilian I. Plotkin, Arancha R. Gortazar, Hannah M. Davis, Keith W. Condon, Hugo Gabilondo, Marta Maycas, Matthew R. Allen, Teresita Bellido

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Background: Osteocyte apoptosis precedes bone loss induced by reduced mechanical forces, and unloading increases RANKL expression. Results: Inhibition of osteocyte apoptosis prevents increased osteocytic RANKL but not bone loss induced by tail suspension. Conclusion: Prevention of apoptosis and reduction of osteocyticRANKLare not sufficient to stop unloading-induced bone loss. Significance: RANKL from non-osteocytic sources contributes to bone loss induced by reduced mechanical forces.

Original languageEnglish (US)
Pages (from-to)18934-18942
Number of pages9
JournalJournal of Biological Chemistry
Volume290
Issue number31
DOIs
StatePublished - Jul 31 2015

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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