Inhibition of polymorphonuclear leukocyte adherence by prostacyclin

Laurence A. Boxer, John M. Allen, Michael Schmidt, Mervin Yoder, Robert L. Baehner

Research output: Contribution to journalArticle

118 Scopus citations

Abstract

The adherence of human PMNs to nylon fibers or endothelial cells is inhibited by exposure in vitro of the phagocytic cells to PGI2. The impaired adherence is transient and correlates with a rise in intracellular levels of cyclic AMP. Similarly, stimulation of human endothelial cells with sodium arachidonate, a precursor of PGI2, leads to impaired PMN adherence. On the other hand, PGI2 failed to alter O2- release and the bactericidal capacity of the PMNs. These findings suggest that PGI2 may play a role in regulating PMN adhesiveness to endothelial cells without compromising host defense.

Original languageEnglish (US)
Pages (from-to)672-678
Number of pages7
JournalThe Journal of Laboratory and Clinical Medicine
Volume95
Issue number5
StatePublished - May 1980

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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    Boxer, L. A., Allen, J. M., Schmidt, M., Yoder, M., & Baehner, R. L. (1980). Inhibition of polymorphonuclear leukocyte adherence by prostacyclin. The Journal of Laboratory and Clinical Medicine, 95(5), 672-678.