Inhibition of polymorphonuclear leukocyte adherence by prostacyclin

Laurence A. Boxer, John M. Allen, Michael Schmidt, Mervin Yoder, Robert L. Baehner

Research output: Contribution to journalArticle

118 Citations (Scopus)

Abstract

The adherence of human PMNs to nylon fibers or endothelial cells is inhibited by exposure in vitro of the phagocytic cells to PGI2. The impaired adherence is transient and correlates with a rise in intracellular levels of cyclic AMP. Similarly, stimulation of human endothelial cells with sodium arachidonate, a precursor of PGI2, leads to impaired PMN adherence. On the other hand, PGI2 failed to alter O2- release and the bactericidal capacity of the PMNs. These findings suggest that PGI2 may play a role in regulating PMN adhesiveness to endothelial cells without compromising host defense.

Original languageEnglish
Pages (from-to)672-678
Number of pages7
JournalJournal of Laboratory and Clinical Medicine
Volume95
Issue number5
StatePublished - 1980

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Epoprostenol
Endothelial cells
Neutrophils
Endothelial Cells
Adhesiveness
Nylons
Phagocytes
Arachidonic Acid
Cyclic AMP
Fibers

ASJC Scopus subject areas

  • Medicine(all)
  • Pathology and Forensic Medicine

Cite this

Boxer, L. A., Allen, J. M., Schmidt, M., Yoder, M., & Baehner, R. L. (1980). Inhibition of polymorphonuclear leukocyte adherence by prostacyclin. Journal of Laboratory and Clinical Medicine, 95(5), 672-678.

Inhibition of polymorphonuclear leukocyte adherence by prostacyclin. / Boxer, Laurence A.; Allen, John M.; Schmidt, Michael; Yoder, Mervin; Baehner, Robert L.

In: Journal of Laboratory and Clinical Medicine, Vol. 95, No. 5, 1980, p. 672-678.

Research output: Contribution to journalArticle

Boxer, LA, Allen, JM, Schmidt, M, Yoder, M & Baehner, RL 1980, 'Inhibition of polymorphonuclear leukocyte adherence by prostacyclin', Journal of Laboratory and Clinical Medicine, vol. 95, no. 5, pp. 672-678.
Boxer, Laurence A. ; Allen, John M. ; Schmidt, Michael ; Yoder, Mervin ; Baehner, Robert L. / Inhibition of polymorphonuclear leukocyte adherence by prostacyclin. In: Journal of Laboratory and Clinical Medicine. 1980 ; Vol. 95, No. 5. pp. 672-678.
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