Inhibition of premature ventricular extrastimuli by subthreshold conditioning stimuli

B. T. Skale, M. J. Kallok, E. N. Prystowsky, R. M. Gill, D. P. Zipes

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The purpose of this study was to determine whether trains of subthreshold high frequency conditioning stimuli (333 Hz, 1 ms duration, 2 ms interval) delivered to the canine ventricle inhibited the response to a premature stimulus (S2) more effectively than did a single subthreshold conditioning stimulus. It was found that trains of conditioning stimuli (mean 1.21 mA) inhibited the response to S2 152 ms beyond expiration of the ventricular effective refractory period, whereas a single conditioning stimulus inhibited S2 only 20 ms or less beyond the ventricular effective refractory period. In late diastole, trains of conditioning stimuli failed to inhibit S2 when the train of stimuli caused ventricular depolarization or the latter occurred in response to the next sinus impulse. Trains of conditioning stimuli did not induce ventricular arrhythmias. Lidocaine or autonomic blockade did not alter the response to trains of conditioning stimuli. Trains of conditioning stimuli or a single conditioning stimulus inhibited the response to S2 only when they were delivered at the same electrode site. By lengthening the ventricular effective refractory period, trains of conditioning stimuli could prevent or terminate tachycardias, but this possibility is constrained, at present, by the spatial limitations of the technique.

Original languageEnglish (US)
Pages (from-to)133-140
Number of pages8
JournalJournal of the American College of Cardiology
Volume6
Issue number1
StatePublished - 1985
Externally publishedYes

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Diastole
Lidocaine
Tachycardia
Canidae
Cardiac Arrhythmias
Electrodes

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Skale, B. T., Kallok, M. J., Prystowsky, E. N., Gill, R. M., & Zipes, D. P. (1985). Inhibition of premature ventricular extrastimuli by subthreshold conditioning stimuli. Journal of the American College of Cardiology, 6(1), 133-140.

Inhibition of premature ventricular extrastimuli by subthreshold conditioning stimuli. / Skale, B. T.; Kallok, M. J.; Prystowsky, E. N.; Gill, R. M.; Zipes, D. P.

In: Journal of the American College of Cardiology, Vol. 6, No. 1, 1985, p. 133-140.

Research output: Contribution to journalArticle

Skale, BT, Kallok, MJ, Prystowsky, EN, Gill, RM & Zipes, DP 1985, 'Inhibition of premature ventricular extrastimuli by subthreshold conditioning stimuli', Journal of the American College of Cardiology, vol. 6, no. 1, pp. 133-140.
Skale, B. T. ; Kallok, M. J. ; Prystowsky, E. N. ; Gill, R. M. ; Zipes, D. P. / Inhibition of premature ventricular extrastimuli by subthreshold conditioning stimuli. In: Journal of the American College of Cardiology. 1985 ; Vol. 6, No. 1. pp. 133-140.
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