The infusion of PGE2 into TPTX dogs abolishes the phosphaturic action of PTH in vivo. This effect occurs only if PGE2 infusion precedes the administration of PTH. The infusion of PGE2 in vivo induces a state of refractoriness of PTH-sensitive adenyiate cyclase in renal middle medulla from TPTX dogs in vitro. These results suggest that PGE2 inhibits the biological effects of PTH, in part by altering the events related to PTH activation of renal adenyiate cyclase. These effects of PGE2, a local mediator, suggest that the renal tubular cell may modulate its responses to multiple and antagonistic stimuli by altering local renal prostaglandins.
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