NMDA receptor agonists selectively and effectively depress the N-type Ca2+ channels in hippocampal pyramidal neurones isolated from young rats. The inhibitory effect is eliminated by the competitive NMDA antagonist D-2-amino-5-phosphonovalerate (APV), does not require Ca2+ entry into the cell and is most probably receptor-mediated. This phenomenon may provide a negative feed-back between the liberation of excitatory transmitter and entry of Ca2+ into the cell. It may be of importance both in presynaptic inhibition and in the regulation of synaptic plasticity.
|Original language||English (US)|
|Number of pages||3|
|Issue number||SUPPL. 2|
|State||Published - Dec 1 1991|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)