Inhibitory action of NMDA-type receptors on N-type Ca channels in hippocampal neurones

O. A. Krishtal, N. I. Chernevskaya, A. G. Obukhov

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Abstract

NMDA receptor agonists selectively and effectively depress the N-type Ca2+ channels in hippocampal pyramidal neurones isolated from young rats. The inhibitory effect is eliminated by the competitive NMDA antagonist D-2-amino-5-phosphonovalerate (APV), does not require Ca2+ entry into the cell and is most probably receptor-mediated. This phenomenon may provide a negative feed-back between the liberation of excitatory transmitter and entry of Ca2+ into the cell. It may be of importance both in presynaptic inhibition and in the regulation of synaptic plasticity.

Original languageEnglish (US)
Pages (from-to)67-69
Number of pages3
JournalBiomedical Research
Volume12
Issue numberSUPPL. 2
StatePublished - Dec 1 1991

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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