Inhibitory action of NMDA-type receptors on N-type Ca channels in hippocampal neurones

O. A. Krishtal, N. I. Chernevskaya, Alexander Obukhov

Research output: Contribution to journalArticle

Abstract

NMDA receptor agonists selectively and effectively depress the N-type Ca2+ channels in hippocampal pyramidal neurones isolated from young rats. The inhibitory effect is eliminated by the competitive NMDA antagonist D-2-amino-5-phosphonovalerate (APV), does not require Ca2+ entry into the cell and is most probably receptor-mediated. This phenomenon may provide a negative feed-back between the liberation of excitatory transmitter and entry of Ca2+ into the cell. It may be of importance both in presynaptic inhibition and in the regulation of synaptic plasticity.

Original languageEnglish (US)
Pages (from-to)67-69
Number of pages3
JournalBiomedical Research
Volume12
Issue numberSUPPL. 2
StatePublished - 1991
Externally publishedYes

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2-Amino-5-phosphonovalerate
N-Methylaspartate
N-Methyl-D-Aspartate Receptors
Neurons
Plasticity
Rats
Transmitters
Feedback
Neuronal Plasticity
Pyramidal Cells

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Inhibitory action of NMDA-type receptors on N-type Ca channels in hippocampal neurones. / Krishtal, O. A.; Chernevskaya, N. I.; Obukhov, Alexander.

In: Biomedical Research, Vol. 12, No. SUPPL. 2, 1991, p. 67-69.

Research output: Contribution to journalArticle

Krishtal, O. A. ; Chernevskaya, N. I. ; Obukhov, Alexander. / Inhibitory action of NMDA-type receptors on N-type Ca channels in hippocampal neurones. In: Biomedical Research. 1991 ; Vol. 12, No. SUPPL. 2. pp. 67-69.
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