Inhibitory proteins against axon regeneration in the central nervous system

Jian Guo Hu, Pei Hua Lu, Xiao-Ming Xu

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Growth inhibition in the central nervous system (CNS) is a majar barrier to axon regeneration. To date, three inhibitory proteins of oligodendrocytes/myelin have been identified: myelin associated glycoprotein ( MAG) , Nogo-A and oligodendrocyte-myelin glycoprotein (OMgp). Recently, findings indicate that three distinct myelin components inhibit axon growth by binding a common receptor, the Nogo 66 receptor (NgR). These novel findings lead to further understanding of the barriers to axon regeneration after injury in the CNS and provide new avenues to explore the new theraphy strategy for the CNS injury.

Original languageEnglish (US)
Pages (from-to)311-314
Number of pages4
JournalSheng li ke xue jin zhan [Progress in physiology]
Volume35
Issue number4
StatePublished - 2004
Externally publishedYes

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Axons
Regeneration
Central Nervous System
Oligodendrocyte-Myelin Glycoprotein
Myelin-Associated Glycoprotein
Myelin Proteins
Nervous System Trauma
Proteins
Oligodendroglia
Growth
Myelin Sheath
Wounds and Injuries
Nogo Receptor 1

Cite this

Inhibitory proteins against axon regeneration in the central nervous system. / Hu, Jian Guo; Lu, Pei Hua; Xu, Xiao-Ming.

In: Sheng li ke xue jin zhan [Progress in physiology], Vol. 35, No. 4, 2004, p. 311-314.

Research output: Contribution to journalArticle

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