Inhibitory proteins against axon regeneration in the central nervous system

Jian Guo Hu, Pei Hua Lu, Xiao min Xu

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Growth inhibition in the central nervous system (CNS) is a majar barrier to axon regeneration. To date, three inhibitory proteins of oligodendrocytes/myelin have been identified: myelin associated glycoprotein ( MAG) , Nogo-A and oligodendrocyte-myelin glycoprotein (OMgp). Recently, findings indicate that three distinct myelin components inhibit axon growth by binding a common receptor, the Nogo 66 receptor (NgR). These novel findings lead to further understanding of the barriers to axon regeneration after injury in the CNS and provide new avenues to explore the new theraphy strategy for the CNS injury.

Original languageEnglish (US)
Pages (from-to)311-314
Number of pages4
JournalSheng li ke xue jin zhan [Progress in physiology]
Volume35
Issue number4
StatePublished - Oct 2004

Fingerprint

Axons
Regeneration
Central Nervous System
Oligodendrocyte-Myelin Glycoprotein
Myelin-Associated Glycoprotein
Myelin Proteins
Nervous System Trauma
Proteins
Oligodendroglia
Growth
Myelin Sheath
Wounds and Injuries
Nogo Receptor 1

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Inhibitory proteins against axon regeneration in the central nervous system. / Hu, Jian Guo; Lu, Pei Hua; Xu, Xiao min.

In: Sheng li ke xue jin zhan [Progress in physiology], Vol. 35, No. 4, 10.2004, p. 311-314.

Research output: Contribution to journalReview article

@article{24eb097c2d4b4027a775c349d84759c4,
title = "Inhibitory proteins against axon regeneration in the central nervous system",
abstract = "Growth inhibition in the central nervous system (CNS) is a majar barrier to axon regeneration. To date, three inhibitory proteins of oligodendrocytes/myelin have been identified: myelin associated glycoprotein ( MAG) , Nogo-A and oligodendrocyte-myelin glycoprotein (OMgp). Recently, findings indicate that three distinct myelin components inhibit axon growth by binding a common receptor, the Nogo 66 receptor (NgR). These novel findings lead to further understanding of the barriers to axon regeneration after injury in the CNS and provide new avenues to explore the new theraphy strategy for the CNS injury.",
author = "Hu, {Jian Guo} and Lu, {Pei Hua} and Xu, {Xiao min}",
year = "2004",
month = "10",
language = "English (US)",
volume = "35",
pages = "311--314",
journal = "Sheng li ke xue jin zhan [Progress in physiology]",
issn = "0559-7765",
publisher = "Neuroscience Research Institute",
number = "4",

}

TY - JOUR

T1 - Inhibitory proteins against axon regeneration in the central nervous system

AU - Hu, Jian Guo

AU - Lu, Pei Hua

AU - Xu, Xiao min

PY - 2004/10

Y1 - 2004/10

N2 - Growth inhibition in the central nervous system (CNS) is a majar barrier to axon regeneration. To date, three inhibitory proteins of oligodendrocytes/myelin have been identified: myelin associated glycoprotein ( MAG) , Nogo-A and oligodendrocyte-myelin glycoprotein (OMgp). Recently, findings indicate that three distinct myelin components inhibit axon growth by binding a common receptor, the Nogo 66 receptor (NgR). These novel findings lead to further understanding of the barriers to axon regeneration after injury in the CNS and provide new avenues to explore the new theraphy strategy for the CNS injury.

AB - Growth inhibition in the central nervous system (CNS) is a majar barrier to axon regeneration. To date, three inhibitory proteins of oligodendrocytes/myelin have been identified: myelin associated glycoprotein ( MAG) , Nogo-A and oligodendrocyte-myelin glycoprotein (OMgp). Recently, findings indicate that three distinct myelin components inhibit axon growth by binding a common receptor, the Nogo 66 receptor (NgR). These novel findings lead to further understanding of the barriers to axon regeneration after injury in the CNS and provide new avenues to explore the new theraphy strategy for the CNS injury.

UR - http://www.scopus.com/inward/record.url?scp=22344457733&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=22344457733&partnerID=8YFLogxK

M3 - Review article

C2 - 15727207

AN - SCOPUS:22344457733

VL - 35

SP - 311

EP - 314

JO - Sheng li ke xue jin zhan [Progress in physiology]

JF - Sheng li ke xue jin zhan [Progress in physiology]

SN - 0559-7765

IS - 4

ER -