Initial genome scan of the NIMH genetics initiative bipolar pedigrees

Chromosomes 4, 7, 9, 18, 19, 20, and 21q

Sevilla D. Detera-Wadleigh, Judith A. Badner, Takeo Yoshikawa, Alan R. Sanders, Lynn R. Goldin, Gordon Turner, Denise Y. Rolling, Tracy Moses, Juliet J. Guroff, Diane Kazuba, Mary E. Maxwell, Howard Edenberg, Tatiana Foroud, Debomoy Lahiri, John Nurnberger, O. Colin Stine, Francis McMahon, Deborah A. Meyers, Dean MacKinnon, Sylvia Simpson & 7 others Melvin McInnis, J. Raymond DePaulo, John Rice, Alison Goate, Theodore Reich, Mary C. Blehar, Elliot S. Gershon

Research output: Contribution to journalArticle

114 Citations (Scopus)

Abstract

An initial genome scan was performed on 540 individuals from 97 families segregating bipolar disorder, collected through the National Institutes of Mental Health Genetics Initiative. We report here affected-sib-pair (ASP) data on 126 marker loci (≃68,000 genotypes) mapping to chromosomes 4, 7, 9, 18, 19, 20, and 21q, under three affection status models. Modest increases in identical-by-descent (IBD) allele sharing were found at the following loci: D4S2397 and D4S391 (P < 0.05) on 4p, D4S1647 (P < 0.05) on 4q, D7S1802 and D7S1869 (low P = 0.01) on 7p, D9S302 (P = 0.004) on 9q, and D20S604 on 20p and D20S173 on 20q (P ≤ 0.05). In addition, five markers on 7q displayed increased IBD sharing (P = 0.046-0.002). Additional ASP analyses on chromosomes 18 and 21q marker data were performed using disease phenotype models defined previously. On chromosome 18, only D18S40 on 18p and D18S70 on 18q yielded a slight elevation in allele sharing (P = 0.02), implying that the reported linkages in these regions were not confirmed. On chromosome 21q, a cluster of markers within an ≃9 cM interval: D21S1254, D21S65, D21S1440, and D21S1255 exhibited excess allele sharing (P = 0.041-0.008). Multilocus data on overlapping marker quartets, from D21S1265 to D21S1255, which were consistent with increased IBD sharing (P < 0.01, with a low of 0.0009), overlapped a broad interval of excess allele sharing reported previously, increasing support for a susceptibility locus for bipolar disorder on 21q.

Original languageEnglish
Pages (from-to)254-262
Number of pages9
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume74
Issue number3
DOIs
StatePublished - 1997

Fingerprint

National Institute of Mental Health (U.S.)
Chromosomes, Human, Pair 4
Chromosomes, Human, Pair 7
Pedigree
Alleles
Genome
Chromosomes, Human, Pair 18
Bipolar Disorder
Chromosomes
Genotype
Phenotype

Keywords

  • Bipolar disorder
  • Bipolar pedigree
  • Genome scan
  • Linkage

ASJC Scopus subject areas

  • Genetics(clinical)
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)

Cite this

Initial genome scan of the NIMH genetics initiative bipolar pedigrees : Chromosomes 4, 7, 9, 18, 19, 20, and 21q. / Detera-Wadleigh, Sevilla D.; Badner, Judith A.; Yoshikawa, Takeo; Sanders, Alan R.; Goldin, Lynn R.; Turner, Gordon; Rolling, Denise Y.; Moses, Tracy; Guroff, Juliet J.; Kazuba, Diane; Maxwell, Mary E.; Edenberg, Howard; Foroud, Tatiana; Lahiri, Debomoy; Nurnberger, John; Stine, O. Colin; McMahon, Francis; Meyers, Deborah A.; MacKinnon, Dean; Simpson, Sylvia; McInnis, Melvin; DePaulo, J. Raymond; Rice, John; Goate, Alison; Reich, Theodore; Blehar, Mary C.; Gershon, Elliot S.

In: American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, Vol. 74, No. 3, 1997, p. 254-262.

Research output: Contribution to journalArticle

Detera-Wadleigh, SD, Badner, JA, Yoshikawa, T, Sanders, AR, Goldin, LR, Turner, G, Rolling, DY, Moses, T, Guroff, JJ, Kazuba, D, Maxwell, ME, Edenberg, H, Foroud, T, Lahiri, D, Nurnberger, J, Stine, OC, McMahon, F, Meyers, DA, MacKinnon, D, Simpson, S, McInnis, M, DePaulo, JR, Rice, J, Goate, A, Reich, T, Blehar, MC & Gershon, ES 1997, 'Initial genome scan of the NIMH genetics initiative bipolar pedigrees: Chromosomes 4, 7, 9, 18, 19, 20, and 21q', American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, vol. 74, no. 3, pp. 254-262. https://doi.org/10.1002/(SICI)1096-8628(19970531)74:3<254::AID-AJMG4>3.0.CO;2-Q
Detera-Wadleigh, Sevilla D. ; Badner, Judith A. ; Yoshikawa, Takeo ; Sanders, Alan R. ; Goldin, Lynn R. ; Turner, Gordon ; Rolling, Denise Y. ; Moses, Tracy ; Guroff, Juliet J. ; Kazuba, Diane ; Maxwell, Mary E. ; Edenberg, Howard ; Foroud, Tatiana ; Lahiri, Debomoy ; Nurnberger, John ; Stine, O. Colin ; McMahon, Francis ; Meyers, Deborah A. ; MacKinnon, Dean ; Simpson, Sylvia ; McInnis, Melvin ; DePaulo, J. Raymond ; Rice, John ; Goate, Alison ; Reich, Theodore ; Blehar, Mary C. ; Gershon, Elliot S. / Initial genome scan of the NIMH genetics initiative bipolar pedigrees : Chromosomes 4, 7, 9, 18, 19, 20, and 21q. In: American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 1997 ; Vol. 74, No. 3. pp. 254-262.
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abstract = "An initial genome scan was performed on 540 individuals from 97 families segregating bipolar disorder, collected through the National Institutes of Mental Health Genetics Initiative. We report here affected-sib-pair (ASP) data on 126 marker loci (≃68,000 genotypes) mapping to chromosomes 4, 7, 9, 18, 19, 20, and 21q, under three affection status models. Modest increases in identical-by-descent (IBD) allele sharing were found at the following loci: D4S2397 and D4S391 (P < 0.05) on 4p, D4S1647 (P < 0.05) on 4q, D7S1802 and D7S1869 (low P = 0.01) on 7p, D9S302 (P = 0.004) on 9q, and D20S604 on 20p and D20S173 on 20q (P ≤ 0.05). In addition, five markers on 7q displayed increased IBD sharing (P = 0.046-0.002). Additional ASP analyses on chromosomes 18 and 21q marker data were performed using disease phenotype models defined previously. On chromosome 18, only D18S40 on 18p and D18S70 on 18q yielded a slight elevation in allele sharing (P = 0.02), implying that the reported linkages in these regions were not confirmed. On chromosome 21q, a cluster of markers within an ≃9 cM interval: D21S1254, D21S65, D21S1440, and D21S1255 exhibited excess allele sharing (P = 0.041-0.008). Multilocus data on overlapping marker quartets, from D21S1265 to D21S1255, which were consistent with increased IBD sharing (P < 0.01, with a low of 0.0009), overlapped a broad interval of excess allele sharing reported previously, increasing support for a susceptibility locus for bipolar disorder on 21q.",
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T1 - Initial genome scan of the NIMH genetics initiative bipolar pedigrees

T2 - Chromosomes 4, 7, 9, 18, 19, 20, and 21q

AU - Detera-Wadleigh, Sevilla D.

AU - Badner, Judith A.

AU - Yoshikawa, Takeo

AU - Sanders, Alan R.

AU - Goldin, Lynn R.

AU - Turner, Gordon

AU - Rolling, Denise Y.

AU - Moses, Tracy

AU - Guroff, Juliet J.

AU - Kazuba, Diane

AU - Maxwell, Mary E.

AU - Edenberg, Howard

AU - Foroud, Tatiana

AU - Lahiri, Debomoy

AU - Nurnberger, John

AU - Stine, O. Colin

AU - McMahon, Francis

AU - Meyers, Deborah A.

AU - MacKinnon, Dean

AU - Simpson, Sylvia

AU - McInnis, Melvin

AU - DePaulo, J. Raymond

AU - Rice, John

AU - Goate, Alison

AU - Reich, Theodore

AU - Blehar, Mary C.

AU - Gershon, Elliot S.

PY - 1997

Y1 - 1997

N2 - An initial genome scan was performed on 540 individuals from 97 families segregating bipolar disorder, collected through the National Institutes of Mental Health Genetics Initiative. We report here affected-sib-pair (ASP) data on 126 marker loci (≃68,000 genotypes) mapping to chromosomes 4, 7, 9, 18, 19, 20, and 21q, under three affection status models. Modest increases in identical-by-descent (IBD) allele sharing were found at the following loci: D4S2397 and D4S391 (P < 0.05) on 4p, D4S1647 (P < 0.05) on 4q, D7S1802 and D7S1869 (low P = 0.01) on 7p, D9S302 (P = 0.004) on 9q, and D20S604 on 20p and D20S173 on 20q (P ≤ 0.05). In addition, five markers on 7q displayed increased IBD sharing (P = 0.046-0.002). Additional ASP analyses on chromosomes 18 and 21q marker data were performed using disease phenotype models defined previously. On chromosome 18, only D18S40 on 18p and D18S70 on 18q yielded a slight elevation in allele sharing (P = 0.02), implying that the reported linkages in these regions were not confirmed. On chromosome 21q, a cluster of markers within an ≃9 cM interval: D21S1254, D21S65, D21S1440, and D21S1255 exhibited excess allele sharing (P = 0.041-0.008). Multilocus data on overlapping marker quartets, from D21S1265 to D21S1255, which were consistent with increased IBD sharing (P < 0.01, with a low of 0.0009), overlapped a broad interval of excess allele sharing reported previously, increasing support for a susceptibility locus for bipolar disorder on 21q.

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