Inoculated mouse model of Pneumocystis carinii infection

Marilyn S. Bartlett, Sherry F. Queener, Michelle M. Durkin, Margaret A. Shaw, James W. Smith

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

A transtracheally inoculated mouse model of Pneumocystis carinii has been developed using BALB/c mice. The advantage of this strain of mice include that they are widely available, inexpensive, and were not infected with Pneumocystis before inoculation. Inoculated mice that were not treated had a mean infectivity score of 4.1 compared with inoculated mice treated with the effective anti-Pneumocystis drug combination of trimethoprim plus sulfamethoxazole, which had a mean infectivity score of 0.1, an ≈ 4 log difference. The inoculated BALB/c mouse provides a model to serve as a valuable addition to rat models currently used, providing a source of organisms from a different host for cross-species comparisons and for studies of drug efficacy for therapy and prophylaxis. The inoculated mouse is especially cost effective and allows testing of compounds in short supply.

Original languageEnglish (US)
Pages (from-to)129-134
Number of pages6
JournalDiagnostic Microbiology and Infectious Disease
Volume15
Issue number2
DOIs
StatePublished - Feb 1992

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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