Inoculated mouse model of Pneumocystis carinii pneumonia.

M. S. Bartlett, Sherry Queener, M. M. Durkin, M. M. Shaw, J. W. Smith

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A transtracheally inoculated mouse model of Pneumocystis carinii has been developed using BALB/c mice, a widely available strain free of latent P. carinii infection. The mean infectivity score of untreated inoculated mice was 4.1 compared to the mean infectivity score of 0.1 for trimethoprim/sulfamethoxazole (50/250 mg/kg) treated inoculated mice, approximately a four-log difference. An inoculated mouse model of P. carinii infection provides both a source of organisms from a different host and an animal model for study of drugs for therapy and prophylaxis which is less costly than rats and which requires less drug than required for rats.

Original languageEnglish
JournalJournal of Protozoology
Volume38
Issue number6
StatePublished - Nov 1991

Fingerprint

Pneumocystis Pneumonia
Pneumocystis Infections
Pneumocystis carinii
Sulfamethoxazole Drug Combination Trimethoprim
Animal Models
Drug Therapy
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Parasitology

Cite this

Bartlett, M. S., Queener, S., Durkin, M. M., Shaw, M. M., & Smith, J. W. (1991). Inoculated mouse model of Pneumocystis carinii pneumonia. Journal of Protozoology, 38(6).

Inoculated mouse model of Pneumocystis carinii pneumonia. / Bartlett, M. S.; Queener, Sherry; Durkin, M. M.; Shaw, M. M.; Smith, J. W.

In: Journal of Protozoology, Vol. 38, No. 6, 11.1991.

Research output: Contribution to journalArticle

Bartlett, MS, Queener, S, Durkin, MM, Shaw, MM & Smith, JW 1991, 'Inoculated mouse model of Pneumocystis carinii pneumonia.', Journal of Protozoology, vol. 38, no. 6.
Bartlett MS, Queener S, Durkin MM, Shaw MM, Smith JW. Inoculated mouse model of Pneumocystis carinii pneumonia. Journal of Protozoology. 1991 Nov;38(6).
Bartlett, M. S. ; Queener, Sherry ; Durkin, M. M. ; Shaw, M. M. ; Smith, J. W. / Inoculated mouse model of Pneumocystis carinii pneumonia. In: Journal of Protozoology. 1991 ; Vol. 38, No. 6.
@article{7a51ccffcc174742b42c8514a9d11c6b,
title = "Inoculated mouse model of Pneumocystis carinii pneumonia.",
abstract = "A transtracheally inoculated mouse model of Pneumocystis carinii has been developed using BALB/c mice, a widely available strain free of latent P. carinii infection. The mean infectivity score of untreated inoculated mice was 4.1 compared to the mean infectivity score of 0.1 for trimethoprim/sulfamethoxazole (50/250 mg/kg) treated inoculated mice, approximately a four-log difference. An inoculated mouse model of P. carinii infection provides both a source of organisms from a different host and an animal model for study of drugs for therapy and prophylaxis which is less costly than rats and which requires less drug than required for rats.",
author = "Bartlett, {M. S.} and Sherry Queener and Durkin, {M. M.} and Shaw, {M. M.} and Smith, {J. W.}",
year = "1991",
month = "11",
language = "English",
volume = "38",
journal = "Journal of Eukaryotic Microbiology",
issn = "1066-5234",
publisher = "Wiley-Blackwell",
number = "6",

}

TY - JOUR

T1 - Inoculated mouse model of Pneumocystis carinii pneumonia.

AU - Bartlett, M. S.

AU - Queener, Sherry

AU - Durkin, M. M.

AU - Shaw, M. M.

AU - Smith, J. W.

PY - 1991/11

Y1 - 1991/11

N2 - A transtracheally inoculated mouse model of Pneumocystis carinii has been developed using BALB/c mice, a widely available strain free of latent P. carinii infection. The mean infectivity score of untreated inoculated mice was 4.1 compared to the mean infectivity score of 0.1 for trimethoprim/sulfamethoxazole (50/250 mg/kg) treated inoculated mice, approximately a four-log difference. An inoculated mouse model of P. carinii infection provides both a source of organisms from a different host and an animal model for study of drugs for therapy and prophylaxis which is less costly than rats and which requires less drug than required for rats.

AB - A transtracheally inoculated mouse model of Pneumocystis carinii has been developed using BALB/c mice, a widely available strain free of latent P. carinii infection. The mean infectivity score of untreated inoculated mice was 4.1 compared to the mean infectivity score of 0.1 for trimethoprim/sulfamethoxazole (50/250 mg/kg) treated inoculated mice, approximately a four-log difference. An inoculated mouse model of P. carinii infection provides both a source of organisms from a different host and an animal model for study of drugs for therapy and prophylaxis which is less costly than rats and which requires less drug than required for rats.

UR - http://www.scopus.com/inward/record.url?scp=0026253580&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026253580&partnerID=8YFLogxK

M3 - Article

C2 - 1818136

AN - SCOPUS:0026253580

VL - 38

JO - Journal of Eukaryotic Microbiology

JF - Journal of Eukaryotic Microbiology

SN - 1066-5234

IS - 6

ER -