Inoculated mouse model of Pneumocystis carinii pneumonia.

M. S. Bartlett, S. F. Queener, M. M. Durkin, M. M. Shaw, J. W. Smith

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

A transtracheally inoculated mouse model of Pneumocystis carinii has been developed using BALB/c mice, a widely available strain free of latent P. carinii infection. The mean infectivity score of untreated inoculated mice was 4.1 compared to the mean infectivity score of 0.1 for trimethoprim/sulfamethoxazole (50/250 mg/kg) treated inoculated mice, approximately a four-log difference. An inoculated mouse model of P. carinii infection provides both a source of organisms from a different host and an animal model for study of drugs for therapy and prophylaxis which is less costly than rats and which requires less drug than required for rats.

Original languageEnglish (US)
Pages (from-to)130S-131S
JournalThe Journal of Protozoology
Volume38
Issue number6
StatePublished - 1991

ASJC Scopus subject areas

  • Parasitology

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