INSL3/LGR8 role in testicular descent and cryptorchidism

Natalia Bogatcheva, A. I. Agoulnik

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Cryptorchidism, generally referred to a failure of testicular descent into the scrotum, is the most frequent (no 3-4% at birth) congenital anomaly in newborn boys. Cryptorchidism is closely associated with impaired fertility, and represent an established risk factor for testicular cancer. Like other genital defects, cryptorchidism is believed to be caused by either endocrine or genetic abnormalities, or both. Recent elucidation of the molecular mechanism of the rodent testicular descent, and, in particular, the critical role of Insl3 (insulin-like 3) and its receptor Great/Lgr8 encouraged the search for naturally occurring mutations in the human homologues of these genes in the affected patient population. Genetic analysis revealed several functionally deleterious mutations in both INSL3 and GREAT/LGR8 genes. However, although some of mutations were found only in cryptorchid patients, it remains to be verified whether there is a causative link between the presence of mutations in INSL3 or GREAT/LGR8 and the undescended testis phenotype in men. The data and analysis of published studies indicate that mutations in these two genes might account for only a small portion of all cases of this disease in the human population.

Original languageEnglish (US)
Pages (from-to)49-54
Number of pages6
JournalReproductive BioMedicine Online
Volume10
Issue number1
StatePublished - Jan 2005
Externally publishedYes

Fingerprint

Cryptorchidism
Mutation
Genes
Scrotum
Testicular Neoplasms
Population
Fertility
Rodentia
Parturition
Newborn Infant
Insulin
Phenotype

Keywords

  • Cryptorchidism
  • GREAT/LGR8
  • Infertility
  • INSL3
  • Male differentiation

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

INSL3/LGR8 role in testicular descent and cryptorchidism. / Bogatcheva, Natalia; Agoulnik, A. I.

In: Reproductive BioMedicine Online, Vol. 10, No. 1, 01.2005, p. 49-54.

Research output: Contribution to journalArticle

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